Genomic Approaches to Posttraumatic Stress Disorder: the Psychiatric Genomic Consortium Initiative

Post-traumatic stress disorder (PTSD) after exposure to a traumatic event is a highly prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent molecular data (h2SNP) indicate moderate to high heritability, yet robust genetic variants for PTSD have not yet been identified and the genetic architecture of this polygenic disorder remains largely unknown.To date, less than ten large-scale genome-wide association studies (GWAS) of PTSD have been published, with findings that highlight the unique challenges for PTSD genomics, including a complex diagnostic entity with contingency of PTSD diagnosis on trauma exposure, and the large genetic diversity of the study populations.

Source: Biological Psychiatry - February 3, 2018 Category: Psychiatry Authors: Caroline M. Nievergelt, Allison E. Ashley-Koch, Shareefa Dalvie, Michael A. Hauser, Rajendra A. Morey, Alicia K. Smith, Monica Uddin Tags: Review Source Type: research