Log in to search using one of your social media accounts:


New determinants for gallstone disease? 

New determinants for gallstone disease?
. Dan Med J. 2018 Feb;65(2): Authors: Shabanzadeh DM Abstract Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A small number of determinants that are believed to affect these mechanisms have been identified until now. However, much of this research on determinants for gallstone disease has been hampered by insufficient study designs and by insufficient assessment of gallstone disease by only assessing the selected minority of people with clinical gallstone disease. 
In a Danish general-population cohort screened for gallstone disease with multiple ultrasound examinations, it was possible to both confirm previously identified determinants and to identify new determinants for gallstone disease. Temporal associations for incident gallstone disease and female sex, BMI, non-HDL cholesterol, and inverse associations for increasing alcohol consumption and cessation of hormone replacement therapy in females were confirmed. New determinants included testosterone and increase in ...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research

Related Links:

Abstract Receptor tyrosine kinases (RTKs) such as the insulin-like growth factor type 1 receptor (IGF-1R) control important biological activities as well as being involved in pathological processes. Due to their supportive nature in many human cancers they have long been considered attractive therapeutic targets. However, lessons learnt from early targeting trials highlight that a simple "active versus inactive" state model with classical kinase-only signaling is overly simplistic and does not describe reality. A vast amount of evidence exists disproving this model and hence provides a rational explanati...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Shahani Noor, Erin D. Milligan
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
DIABETES type 2 symptoms include increased thirst, unexplained weight loss and frequently needing the toilet. Diabetes type 2 develops later in life due to risk factors including being overweight and having high blood pressure. New research has shown that eating in a 6-hour time period can prevent the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study hypothesizes that being either underweight or obese is associated with a higher hospitalization rate. Observational study of 6296 European haemodialysis patients with prospective data collection and follow-up every six months for three years (COSMOS study). The risk of being hospitalized was estimated by a time-dependent Cox regression model and the annual risk (incidence rate ratios, IRR) by Poisson regression. We considered weight loss, weight gain and stable weight. Weight change analyses were also performed after patient stratification according to their baseline BMI. A total of 3096 patients were hospitaliz...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Conclusion: We found that flexible epidermal sensors reported multiple SSEP parameters that were sensitive to focused ultrasound. This work therefore 1) establishes that epidermal electrodes are appropriate for monitoring the integrity of major CNS functionalities through SSEP; and 2) leveraged this technology to explore ultrasound-induced neuromodulation. The sensor technology is well suited for this application because the sensor electrical properties are uninfluenced by direct exposure to ultrasound irradiation. Significance: The sensors and experimental paradigm we present involve standard, safe clinical neurological a...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The proposed simulator can be used to perform credible ISCT in realistic insulin treatment scenarios. Significance: The T1D patient decision simulator can be used to reliably assess novel insulin treatmen- s, e.g., based on use of CGM only, in a realistic multiple-day scenario.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy (DR). Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intra- and intervisit variability in illumination and image quality, the required high registration accuracy, and the subtle appearance of retinal lesions compared to other retinal features. This paper presents a robust and flexible approach for automated detection of longitudinal retinal changes due to small red lesions by exploiting normalized fundus images that significantly reduce il...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The original model morphing algorithm is fast and robust with low computational cost. Significance: This low-cost model morphing algorithm may be highly beneficial for future patient-specific reduced-order modeling of the LV with potential application to other crucial organs.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Drinkers in particular need to be more aware of mounting evidence of links between alcohol and cancer, and make judgements accordingly
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Is the short synacthen test a reliable means of assessing HPA axis recovery after long-term glucocorticoid treatment?Endocrine Practice
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
More News: Alcoholism | Bile | Cardiology | Cardiovascular | Cholecystectomy | Cholesterol | Coffee | Denmark Health | Diabetes | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Gallstones | General Medicine | Genetics | Heart | Hormone Replacement Therapy | Hormones | Insulin | Nutrition | Obesity | Smokers | Study | Ultrasound | Vitamin D | Vitamins