Autonomic conflict exacerbates long QT associated ventricular arrhythmia

This study tested the hypothesis that concomitant sympathetic and parasympathetic stimulation ( “autonomic conflict”) may act as a trigger for arrhythmia in long QT syndrome (LQTS). Studies were performed in isolated innervated rabbit hearts treated with clofilium (100 nmol/L); a potassium channel blocker. The influence of vagus nerve stimulation (VNS) on spontaneous ventricular arrhythm ia was assessed in the absence/presence of sustained noradrenaline perfusion (100 nmol/L) and with sudden adrenergic stress (injections of noradrenaline into the perfusion line).
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research