Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs.

Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs. Cell Mol Life Sci. 2018 Jan 31;: Authors: Goyal N, Kesharwani D, Datta M Abstract Type 2 diabetes is a complex metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease and its complications. Long non-coding RNAs (lncRNAs) are a novel class of functional RNAs that regulate a variety of biological processes by a diverse interplay of mechanisms including recruitment of epigenetic modifiers, transcriptional and post-transcriptional regulation, control of mRNA decay, and sequestration of transcription factors. Although the underlying causes that define the diabetic phenotype are extremely intricate, most of the studies in the last decades were mostly centered on protein-coding genes. However, current opinion in the recent past has authenticated the contributions of diverse lncRNAs as critical regulatory players during the manifestation of diabetes. The current review will highlight the importance of lncRNAs in regulating cellular processes that govern metabolic homeostasis in key metabolic tissues. A more in-depth understanding of lncRNAs may enable their exploitation as biomarkers or for therapeutic applications during diabetes and its associated complications. PMID: 29387902 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research

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Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
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Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
TYPE 2 diabetes is a life-long condition that requires making certain lifestyle changes to avert the risks. A recent study adds to the growing body of evidence which says cutting down on a certain food group can help people manage their condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Authors: Abstract [This corrects the article doi: 10.1590/2175-8239-jbn-2018-0200]. PMID: 31419278 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
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