GSE107630 Acute treatment with chemical PPARGC1a1 activators in brown fat cells

Contributors : Amanda T Pettersson-Klein ; Jorge L RuasSeries Type : Expression profiling by arrayOrganism : Mus musculusThe peroxisome proliferator-activated receptor-coactivator-1 α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation has been suggested to be beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be valuable tools in the fight against obesity and metabolic d isease. Finding such compounds has been challenging partly because PGC-1α1 is a transcriptional coactivator with no known ligand-binding activities. Importantly, PGC-1α1 activation is regulated by several mechanisms but protein stabilization is a limiting step as the protein has a short half-life under unstimulated conditions.We designed a cell-based high-throughput system to identify stabilizers of PGC-1 α1 protein. Positive hits were tested for their ability to induce endogenous PGC-1α1 protein accumulation and activate target gene expression in brown adipocytes. Selected compounds were analyzed for their effects on global gene expression in brown adipocytes.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

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Conclusions: The use of mHealth for obese adults showed a modest short-term effect on body weight and BMI. Although the weight loss associated with mHealth did not meet the recommendation of the Scottish Intercollegiate Guideline Network, which considers a reduction of approximately 5 to 10 kg of the initial body weight as a successful intervention. Well-designed RCTs are needed to reveal the effects of mHealth interventions. PMID: 30788177 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
In North America the most common causes of hepatocellular carcinoma (HCC) are viral hepatitis and alcohol, however with the rise in obesity non-alcoholic steatohepatitis (NASH) induced HCC is becoming more frequent. Transarterial chemoembolization (TACE) has been proven to be an effective therapy in the treatment of HCC, however, to date little data on treatment outcomes of NASH induced HCC treated by TACE is available. Given cirrhotic livers are known to tolerate embolization more than non-cirrhotics it is possible that patients with NASH induced HCC would experience more complications than other patients treated with TACE.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 22: Hepatocellular Carcinoma TACE Source Type: research
This study tracked the utilization of this service from 2014 –17. It also compared diagnostic rates between bedside and fluoroscopic-guided BM biopsies to define decision criteria for determining which patients might benefit most from image guidance.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 39: Needle in a Haystack (Biopsies) Source Type: research
This study describes early experiences testing the feasibility of an autonomous robotic-arm assisted sonography system.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 30: Forget The X-Rays (Imaging) Source Type: research
Extreme obesity is considered a relative contraindication to laparoscopic nephrectomy. Our objective is to evaluate the feasibility and perioperative outcomes of extremely obese patients who underwent thermal ablation for renal cell carcinoma (RCC).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Posters Source Type: research
Conclusions: This is the first study to investigate the genetics of IIH in a rigorously characterized cohort. The study was limited by its modest size and thus would have only been able to demonstrate highly significant association on a genome-wide scale for relatively common alleles exerting large effects. However, several variants and loci were identified that might be strong candidates for follow-up studies in other well-phenotyped cohorts.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
When Tom Shicowich’s toe started feeling numb in 2010, he brushed it off as a temporary ache. At the time, he didn’t have health insurance, so he put off going to the doctor. The toe became infected, and he got so sick that he stayed in bed for two days with what he assumed was the flu. When he finally saw a doctor, the physician immediately sent Shicowich to the emergency room. Several days later, surgeons amputated his toe, and he ended up spending a month in the hospital to recover. Shicowich lost his toe because of complications of Type 2 diabetes as he struggled to keep his blood sugar under control. He wa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health Nutrition Source Type: news
AbstractThe combination of an aging population and an increasing prevalence of diseases associated with impaired-wound healing, including obesity, peripheral vascular disease and diabetes, is likely to result in a dramatic increase in the incidence and prevalence of chronic skin wounds. Indeed, systemic reviews are now not only trying to establish both the prevalence and the often under-estimated socio-economic costs of chronic skin wounds, but most importantly are addressing the impact  that chronic wounds have on quality of life. Given the clear need for novel approaches to the management of chronic skin ulceration,...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Publication date: Available online 21 February 2019Source: NeuroImageAuthor(s): Simon H. Kohl, Ralf Veit, Maartje S. Spetter, Astrid Günther, Andriani Rina, Michael Lührs, Niels Birbaumer, Hubert Preissl, Manfred HallschmidAbstractObesity is associated with altered responses to food stimuli in prefrontal brain networks that mediate inhibitory control of ingestive behavior. In particular, activity of the dorsolateral prefrontal cortex (dlPFC) is reduced in obese compared to normal-weight subjects and has been linked to the success of weight-loss dietary interventions. In a randomized controlled trial in overweight...
Source: NeuroImage - Category: Neuroscience Source Type: research
This study investigated the effect of HSPA12A on the browning of WAT. WAT Browning in mice was induced by cold exposure for 5 days. We observed that nuclear HSPA12A content was increased in WAT after cold exposure, while deficiency of HSPA12A (Hspa12a−/−) promoted the cold-induced browning of WAT in mice compared to wild type (WT) littermates. Accordingly, Hspa12a−/− mice showed attenuation of body temperature drop and increase of thermogenic gene expression compared to WT mice after cold exposure. However, in vitro experiments demonstrated that HSPA12A deficiency in primary white adipocytes did n...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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