GSE107630 Acute treatment with chemical PPARGC1a1 activators in brown fat cells
Contributors : Amanda T Pettersson-Klein ; Jorge L RuasSeries Type : Expression profiling by arrayOrganism : Mus musculusThe peroxisome proliferator-activated receptor-coactivator-1 α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation has been suggested to be beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be valuable tools in the fight against obesity and metabolic d isease. Finding such compounds has been challenging partly because PGC-1α1 is a transcriptional coactivator with no known ligand-binding activities. Importantly, PGC-1α1 activation is regulated by several mechanisms but protein stabilization is a limiting step as the protein has a short half-life under unstimulated conditions.We designed a cell-based high-throughput system to identify stabilizers of PGC-1 α1 protein. Positive hits were tested for their ability to induce endogenous PGC-1α1 protein accumulation and activate target gene expression in brown adipocytes. Selected compounds were analyzed for their effects on global gene expression in brown adipocytes.
Type 2 diabetes is a pandemic disease with an incidence that has risen steadily over recent decades. Experimental evidence in animals has demonstrated that intestinal bypass surgery of the upper small intestine, particularly the duodenum, has an important role in glucose homoeostasis. Furthermore, Roux-en-Y bypass performed as bariatric surgery has shown to correct hyperglycaemia from the first postoperative days in obese diabetic patients. Therefore, on the basis of these considerations, duodenal mucosal resurfacing was studied in type 2 diabetes patients as a minimally invasive procedure that could offer an alternative t...
Are menopausal vasomotor symptoms associated with increased risk of obstructive sleep apnea, independent of obesity?Menopause
When it comes to pegging the blame for the obesity crisis, farm subsidies are a popular target. Subsidies, the argument goes, encourage farmers to grow less-healthy foods — corn, turned into corn syrup, is the common culprit here — and fewer unsubsidized fruits and vegetables.Not everyone agrees. Experts caution that cheap corn isn't the only cause of poor nutrition and that other factors, like technology, are responsible for the low cost of field crops. Still, it's reasonable to ask: How can subsidies be used to make healthier food options more available?One answer: by making sure that subsidies take into acco...
Youngjo Kim, Princess Wendy Bayona, Miri Kim, Jiyeon Chang, Sunmin Hong, Yoona Park, Andrea Budiman, Yong-Jin Kim, Chang Yong Choi, Woo Seok Kim, Jongsoon Lee, Kae Won Cho
ReviveMed, a Massachusetts Institute of Technology (MIT) spinout, is using artificial intelligence (AI) to unlock the power of metabolomics to discover new therapies to treat diseases. Metabolomics is the large-scale study of small molecules like glucose or cholesterol produced by cellular activity. ReviveMed’s platform could help pharmaceutical companies redesign existing drugs or develop new drugs to help patients suffering from disease. The Cambridge, MA-based company recently raised funding to help further develop its AI solution, closing an oversubscribed seed round of $1.5 million. Rivas Capital led the round, ...
Conclusions: These data point to an unmet patient requirement for a postoperative support group that is independent of weight loss success. More research is required to ascertain how such a group should be delivered, but our data would suggest that supporting patients with weight loss maintenance, body image, and return to work is an important part of postoperative care, and these needs extend well beyond the immediate period of specialist follow-up. PMID: 29666701 [PubMed - in process]
Conclusions Multiple factors were associated with impaired HRQoL. Providing strategies to address potential risk factors such as low income, physically inactive, smoker, and obese or underweight should be considered to improve HRQoL among adults with asthma. PMID: 29667453 [PubMed - as supplied by publisher]
Conclusion: Modifiable factors associated with HDL differ according to sex and menopausal status. Sex and menopausal status should be considered when implementing lifestyle changes to raise HDL. For example, both men and women should maintain a normal weight as well as quit smoking. PMID: 29662650 [PubMed]
Conclusions: Despite the increased incidence of gynecological malignancies in obese, we found no significant impact of BC including VAT on patient survival. Further studies with larger cohorts are needed to quantify BC and its metabolomic impact regarding treatment and prognosis. PMID: 29662648 [PubMed]