Medulloblastoma with myogenic and/or melanotic differentiation does not align immunohistochemically with the genetically defined molecular subgroups

The World Health Organization classification of central nervous system neoplasms (2016 update) recognizes four histological variants and genetically defined molecular subgroups within medulloblastoma (MB). MB with myogenic differentiation is one of the rare variant which is usually recognized as a pattern alongside the known histological variants. Due to its rarity, less is known about its molecular landscape and importantly about its placement in the current molecular schema. We aimed to analyze this rare variant for expression of three immunohistochemical markers conventionally used in molecular stratification of MB.

Source: Human Pathology - February 2, 2018 Category: Pathology Authors: Kirti Gupta, Swathi Jugunoori, Ayusman Satapathy, Pravin Salunke, Narendra Kumar, Bishan Dass Radotra, Rakesh Kumar Vasishta Source Type: research