CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study

CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal, reduced, null or increased activity. It is hypoth...

Source: Malaria Journal - February 1, 2018 Category: Infectious Diseases Authors: Larissa W. Brasil, Fernanda Rodrigues-Soares, Ana B. Santoro, Anne C. G. Almeida, Andrea K ühn, Rajendranath Ramasawmy, Marcus V. G. Lacerda, Wuelton M. Monteiro and Guilherme Suarez-Kurtz Tags: Research Source Type: research