Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy

• Active HLH disease at time of HSCT does not preclude successful patient outcome;• Treosulfan-based regimens resulted in low TRM and rate of graft failure;• HLA-mismatched HSCT was associated with reduced rate of engraftment;• Rejection/secondary graft failure are events that could be salva ged by a 2nd HSCT.

http://www.bbmt.org/article/S1083-8791(18)30038-7/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - February 2, 2018 Category: Hematology Authors: Chiara Messina, Marco Zecca, Franca Fagioli, Attilio Rovelli, Stefano Giardino, Pietro Merli, Fulvio Porta, Maurizio Aric ò, Elena Sieni, Giuseppe Basso, Mimmo Ripaldi, Claudio Favre, Marta Pillon, Antonio Marzollo, Marco Rabusin, Simone Cesaro, Mattia A Source Type: research