Estimated Biopsy Rate Varies After Breast Cancer Treatment
Incidence of breast biopsy higher among women treated with brachytherapy versus whole - breast irradiation
ConclusionsBased on indirect comparisons, no differences in clinical outcomes were observed among diverse APBI techniques in published clinical trials that formally compared WBI to APBI. However wide confidence intervals and high risk of inconsistency precluded a sound conclusion. Further head-to-head clinical trials comparing different APBI techniques are required to confirm our findings. Studies comparing different techniques using individual participant data and/or real-life data from population-based studies/registries could also provide more robust results.
Older ( ≥67 years) breast cancer survivors diagnosed in 2009 and treated with 1 of 5 local-therapy options [lumpectomy plus whole breast irradiation, brachytherapy, or endocrine therapy (Lump+WBI, Lump+Brachy, or Lump-alone) or mastectomy -/+ radiation (Mast-alone or Mast+RT)] were surveyed to examine the ir local-therapy treatment-related decisional regret 6-years after diagnosis. Local-therapy regret afflicted nearly one-quarter of our cohort and was associated with black race, less education, and more extensive nodal dissection but not breast surgery.
We report preliminary results from a novel fractionation scheme that condenses accelerated partial breast irradiation (APBI) to 2 or 3 days. The treatment as delivered is well tolerated with low toxicity. This mimics the convenience of IORT without its limitations.
ConclusionsThe local recurrence risk reduction of the tumour bed boost in breast-conserving therapy is not influenced by the applied boost technique.
We report outcomes of a prospective trial evaluating adjuvant 3-fraction intra-cavitary accelerated partial breast brachytherapy for women with early stage breast cancer. With early follow-up, we have identified low rates of adverse events, favorable patient-reported quality of life, and a high rate of excellent or good breast cosmesis. These data are promising and warrant further study.
Accelerated partial breast irradiation (APBI) is a treatment option for selected early stage breast cancer patients. Some APBI techniques lead to skin toxicity with the skin dose as main risk factor. We hypoth...
Accelerated partial breast irradiation is a treatment option for selected patients with early-stage breast cancer. Some accelerated partial breast irradiation techniques lead to skin toxicity with the skin dose as a main risk factor. Biodegradable spacers are effective and safe in prostate brachytherapy to protect the rectum. We hypothesize that a subcutaneous spacer injection reduces the skin dose in breast brachytherapy.
To evaluate the process and improve safety of intraoperative radiation therapy (IORT) for early-stage breast cancers treated with electronic brachytherapy.
ConclusionThe presented relationships can be developed in each individual institution and convert one dosimetric index to another for different skin definitions.
High-dose-rate, multicatheter interstitial brachytherapy is technically complex and operator-dependent, requiring lengthy training and specialized skills. Furthermore, until the advent of contouring on computerized tomography (CT) images, difficulties existed in locating the target volume precisely. The present article reports the results of a study that aimed at producing and validating a 3D-printed template to aid in target volume localization for multicatheter interstitial brachytherapy in patients with breast cancer.