Scriptaid inhibits cell survival, cell cycle, and promotes apoptosis in multiple myeloma via epigenetic regulation of p21

Multiple myeloma (MM) is malignant hematological disease that leads to approximately 80,000 deaths every year [1]. Many novel therapeutic approaches, including hematopoietic stem cell transplantation, proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, have led to dramatically improved survival for MM patients [2,3]. However, MM remains an incurable disease and its molecular mechanisms require further study.

Source: Experimental Hematology - January 2, 2018 Category: Hematology Authors: Ruosi Yao, Danyang Han, Xiaoyang Sun, Yu Xie, Qingyun Wu, Chunling Fu, Yao Yao, Hujun Li, Zhenyu Li, Kailin Xu Source Type: research