Frailty and the management of hematologic malignancies

The majority of blood cancers occur in the elderly. This fact conspires with an aging population in many countries to make rigorous assessment for frailty increasingly important for hematologic oncologists. In this review, we first define frailty and its relevance for patients with hematologic malignancy. Next, we review current data regarding the effect of domains of frailty on outcomes for blood cancers including myelodysplastic syndromes, acute leukemia, non-Hodgkin lymphomas such as chronic lymphocytic leukemia, and multiple myeloma. Finally, after presenting assessment and treatment options for the practicing hematologist, we propose elements of a new research agenda for geriatric hematology: the exchange of age limits for rigorous frailty screening, development of disease-specific measures, and inclusion of functional and patient-reported outcomes alongside survival.
Source: Blood - Category: Hematology Authors: Tags: Free Research Articles, Myeloid Neoplasia, Lymphoid Neoplasia, Review Articles, Review Series, Clinical Trials and Observations Source Type: research

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BOSTON (CBS) – Alex Fitzpatrick went from Hollywood screenwriter to Massachusetts restaurant owner so she and her husband could spend more time with her children. When she recently found out her risk of getting breast cancer was as high as 80%, all she could think of was her three boys. “I do want to make sure that I’m the one telling them what to wear on their wedding day and watch them go to college,” she said. Alex has one of the BRCA gene mutations. She got tested when an aunt was recently diagnosed with an aggressive form of breast cancer. “I was blindsided to be honest,” she remem...
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