Log in to search using one of your social media accounts:

 

Frailty and the management of hematologic malignancies

The majority of blood cancers occur in the elderly. This fact conspires with an aging population in many countries to make rigorous assessment for frailty increasingly important for hematologic oncologists. In this review, we first define frailty and its relevance for patients with hematologic malignancy. Next, we review current data regarding the effect of domains of frailty on outcomes for blood cancers including myelodysplastic syndromes, acute leukemia, non-Hodgkin lymphomas such as chronic lymphocytic leukemia, and multiple myeloma. Finally, after presenting assessment and treatment options for the practicing hematologist, we propose elements of a new research agenda for geriatric hematology: the exchange of age limits for rigorous frailty screening, development of disease-specific measures, and inclusion of functional and patient-reported outcomes alongside survival.
Source: Blood - Category: Hematology Authors: Tags: Free Research Articles, Myeloid Neoplasia, Lymphoid Neoplasia, Review Articles, Review Series, Clinical Trials and Observations Source Type: research

Related Links:

The thumbnail take on finasteride has been that it prevents prostate cancer but increases the risk for high-grade disease. A new study debunks the latter idea.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Smart technologies can sift through data to help the NHS spot diseases quicker, the PM is to say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
LONDON (Reuters) - Prime Minister Theresa May will call on Britain's health service, charities and artificial intelligence sector to work together to better identify patients with the early stages of cancer and stop thousands dying each year.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This article will discuss those efforts and results to date. PMID: 29766832 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
This study assessed the survival impact of combined surgery to the primary tumor and metastatic disease in the management of metastatic NSCLC. Stage IV NSCLC patients at presentation, diagnosed from 2004 to 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. Propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TN stage, and site of metastases). A total of 144,334 patients were identified. The median age group was 65-70 years, and 1139 patients (0.8% of the patients) have received surgical treatment to both the primary tumor...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
In conclusion, NSUN2 is a potential independent prognostic marker and may be a potential therapeutic target in HNSCC. PMID: 29775108 [PubMed - in process]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
The costs associated with a cancer diagnosis can add to a patient's stress, which can have a negative effect on outcome. Nurses can help by being prepared to discuss the financial aspects of care.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nursing News Source Type: news
[The Conversation Africa] As cancer and other non-infectious diseases continue to rise all over the world it's become harder for scientists to find safe, effective treatments. In addition, bacteria are becoming more and more resistant to drugs and synthetic medicines have become harsher.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Abstract Hypoxia plays a crucial role in cancer progression, and it has great significance for monitoring hypoxic level in biosystems. Cancer stem cells (CSCs) represent a small population of tumour cells that regard as the key to seed tumours. The survival of CSCs depend on the tumour microenvironment, which is distinct region has the hypoxic property. Therefore, the detection of the hypoxic CSC niche plays a pivotal role in the destructing the 'soil' of CSCs, and eliminating CSCs population. Numerous one-photon excited fluorescent probes have been developed to indicate the hypoxic status in tumours through the d...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
In this report, a hydrophilic probe in mesoporous pore (denoted as Fe3O4@mSiO2@G6P) was designed and prepared. By taking advantage of the excellent hydrophilicity and size-exclusion ability, we applied Fe3O4@mSiO2@G6P to capture glycopeptides from both horseradish peroxidase (HRP) and immunoglobulin (IgG) digests successfully. Moreover, a total of 39 and 25 endogenous glycopeptides were identified from healthy saliva and gastric saliva, respectively, indicating the great potential of this probe for the exploration of glycopeptidome biomarkers. PMID: 29776550 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
More News: Acute Leukemia | Cancer | Cancer & Oncology | Chronic Leukemia | Chronic Lymphocytic Leukemia | Clinical Trials | Geriatrics | Hematology | Hodgkin's Disease | Leukemia | Lymphoma | Myelodysplastic Syndrome | Myeloma