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Anemia at older age: etiologies, clinical implications, and management

Anemia is quite frequently diagnosed in older individuals and is a key indicator of various reactive and clonal conditions. Many underlying diseases, like myelodysplastic syndrome (MDS), develop preferentially in elderly individuals. The prevalence of anemia at older age is increasing, and this is mainly attributable to more frequently applied diagnostics and demographic changes in our societies. The etiology of anemia at older age is complex and ranges from bone marrow failure syndromes to chronic kidney disease, and from nutritional deficiencies to inflammatory processes including inflammaging in immunosenescence. In a smaller number of cases, no clear-cut etiology is identified. These patients are referred to as unexplained anemia or idiopathic cytopenia of unknown significance. In others, somatic mutations in leukocytes are found, but diagnostic criteria for MDS or other hematologic diseases are not fulfilled, a condition termed clonal cytopenia of undetermined significance. Management of anemias at older age depends on (1) the severity of the anemia, (2) underlying condition(s), and (3) patient-related factors, including comorbidities. Even a mild anemia may substantially affect physical and cognitive capacities and quality of life. An underestimated aspect is that because of age-related changes, organ function such as erythropoietin production in the kidney may become suboptimal. Management and treatment of anemia in older patients often require a multidisciplinary appr...
Source: Blood - Category: Hematology Authors: Tags: Free Research Articles, Red Cells, Iron, and Erythropoiesis, Review Articles, Review Series, Clinical Trials and Observations Source Type: research

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Conditions:   Healthy;   Thiamine and Niacin Deficiency States;   Pyridoxine Deficiency;   Folic Acid Deficiency Anemia, Dietary;   Vitamin B 12 Deficiency;   Peroxidase; Defect;   Polyphenols;   Oxidative Stress;   Homocystine; Metabolic Disorder Interventions:   Dietary Supplement: Panmol-B-Complex;   Dietary Supplement: Synthetic Vitamin B-Complex Sponsor:   Medical University of Graz Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractMalaria is an infectious and deadly parasitic disease, associated with fever, anaemia and other ailments. Unfortunately the upsurge of plasmodium multidrug resistant constrained researchers to look for new effective drugs. Medicinal plants seem to be an unquenchable source of bioactive principles in the treatment of various diseases. The aim of this study was to assess the antiplasmodial activity of two Ivorian medicinal plants. The in vitro activity was evaluated against clinical isolates andPlasmodium falciparum K1 multidrug resistant strain using the fluorescence based SYBR green I assay. The in vivo bioassay wa...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
FRIDAY, Feb. 23, 2018 -- Chronic kidney disease may affect brain function in children and teens, especially those on dialysis, researchers say. Results of their study review suggest academic assistance may be needed in specific areas, including...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusion: We report a high prevalence of anemia, ID, and IDA among young healthy males participating in prolonged strenuous training programs. These findings can be partly explained by the physiological changes associated with strenuous physical activity. Further investigations aiming to develop specific diagnostic guidelines for this unique population are warranted.Acta Haematol 2018;139:141 –147
Source: Acta Haematologica - Category: Hematology Source Type: research
Conclusions In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
In this study, the genetic cause of congenital, transfusion dependent anemia in four unrelated families consisting of eighteen individuals, with one affected member was investigated. Probands were suspected to rare anemias, including sideroblastic anemia. Whole exome sequencing in probands followed by segregation analysis in families was performed. Two novel frame shift mutations and one previously reported missense mutation in SLC25A38 gene was identified in these families. Mutations and their recessive mood of inheritance in each family were confirmed by PCR and Sanger sequencing. These findings suggest that sideroblasti...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 1 Author(s): Akram M Abu Salah Background Antenatal care is an effective means of reducing risk for the mothers and fetuses during pregnancy. It is intended to prevent obstetric complications by improving the quality of antenatal care, hygiene, and knowledge about signs and symptoms of common medical problems during pregnancy. Low birthweight (<2·5 kg at birth) is an important factor affecting neonatal mortality and a predictor of health of the newborn child. The aim of this study was to assess the association between antenatal care pro...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 2 Author(s): Aeysha Chaudhry, Shakoor Hajat, Najwa Rizkallah, Ala'a Abu-Rub Background Vitamin A and vitamin D are essential for a child's growth and development. However, research on micronutrients in the occupied Palestinian territory is scarce. The aim of this study was to ascertain the prevalence and risk factors of vitamin A and vitamin D deficiencies in children living in the occupied Palestinian territory. Methods The Palestinian Micronutrient Survey in 2013 measured concentrations of vitamin A in 1054 children (569 children in the West Ba...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 2 Author(s): Ahmad Yaseen, Sa'd Suleiman, Omar Abu Zenah, Adham Abu Taha Background Red blood-cell transfusion has greatly reduced the mortality and morbidity in multiply transfused patients with thalassaemia and sickle cell disease. However, this can result in red blood-cell isoimmunisation with autoantibodies and alloantibodies, which can lead to serious complications such as delayed haemolytic transfusion reaction. The aim of this study was to assess the frequency and types of alloantibodies in multiply transfused patients living in the north ...
Source: The Lancet - Category: General Medicine Source Type: research
AbstractMany cardiovascular diseases present renin –angiotensin–aldosterone system (RAAS) hyperactivity as an important pathophysiological mechanism to be target in the therapeutic approaches. Moreover, arterial stiffness is currently considered as a new independent risk factor for cardiovascular disease in different clinical conditions, includi ng hypertension and chronic kidney disease. In fact, excessive stimulation of angiotensin type 1 (AT1) receptors, as well as mineralocorticoid receptors, results in cellular growth, oxidative stress and vascular inflammation, which may lead to arterial stiffness and acc...
Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research
More News: Anemia | Bone Marrow Failure Syndrome (BMFS) | Chronic Kidney Disease | Clinical Trials | Hematology | Iron | Myelodysplastic Syndrome | Nutrition | Urology & Nephrology