Potential new target for reducing osteoporosis risk in men

Researchers have identified a new regulator of vitamin D metabolism that could be targeted to reduce the risk of osteoporosis in men undergoing prostate cancer therapy, according to a study published in theJournal of Molecular Endocrinology.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractA 74-year-old man presented to the Andrology Clinic for management of potential complications of androgen deprivation therapy for prostate cancer. He had a rising prostate-specific antigen with a concurrent rise in alkaline phosphatase and bone remodeling markers. This was despite treatment with a radical prostatectomy, androgen deprivation, and anti-resorptive therapy. A follow-up dual-energy X-ray absorptiometry scan revealed a marked increase in his bone mineral density at both the lumbar spine and femoral neck. This increase, especially in the context of rising bone remodeling markers, was unlikely due to the e...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
CONCLUSIONS: Comprehensive management of the patient with advanced prostate cancer should include the study and treatment of osteoporosis and bone metastases. Currently, very effective therapies are available for both entities. PMID: 29633946 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Metabolic side effects of androgen deprivation therapy (ADT) include diabetes, weight gain, increased fat mass, and osteoporosis. We previously showed in the CAPS1 trial that restricting carb intake in overweight men starting ADT led to weight and fat mass loss, suggestively improved insulin sensitivity, and reduced bone mass loss, thus reducing the risk of ADT-associated side effects vs. a control arm (no lifestyle changes). Here, we present secondary outcomes. We hypothesized a low-carb diet would favorably impact cholesterol, HbA1c, and HsCRP levels (a measure of systemic inflammation) without increasing adverse events (AEs).
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Prostate Cancer: Advanced (including Drug Therapy) II Source Type: research
In this study, changes in bone quality, turnover markers, and BMD after ADT were prospectively evaluated before and after ADT in castration-sensitive prostate cancer.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Prostate Cancer: Advanced (including  Drug Therapy) IV Source Type: research
Publication date: Available online 20 March 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Tilman D Rachner, Robert Coleman, Peyman Hadji, Lorenz C Hofbauer Preservation of bone health remains a long-term clinical challenge in patients with breast and prostate cancer. Osteoporosis, defined by a loss of bone mass and microarchitecture, often results in fragility fractures that are typically associated with a high socioeconomic burden. Endocrine therapy, a mainstay treatment in the management of patients with hormone-sensitive breast and prostate cancer in the adjuvant setting, commonly exerts adverse effect...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Conclusion: Buserelin can induce testosterone deficiency and the associated deterioration of bone microarchitecture similar to orchidectomy in three months. However, it may require a longer time to show significant effects on bone strength and mineral content. PMID: 29511366 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Follow me on Twitter @RobShmerling Let us sing the praises of good medical screening tests. These are the tests that can detect medical problems before they become untreatable and before they cause complications or even death. Even better are those screening tests that detect “predisease” — abnormalities that aren’t dangerous on their own but can lead to problems later. According to the US Preventive Services Task Force, relatively few screening tests are considered good enough to routinely recommend for adults, including mammography for breast cancer (women) Pap smear for cervical cancer (women) b...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Health Prevention Screening Source Type: blogs
n W Abstract Telomeres are the protective end caps of chromosomes and shorten with every cell division. Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases. Epidemiologic studies show an association between leukocyte telomere length (LTL) and mortality. There is solid evidence that links LTL with cardiovascular disease. Short telomeres promote atherosclerosis and impair the repair of vascular lesions. Alzheimer's disease patients have also a reduced LTL. Telomeres measured in tumor tissue from breast, colon and prostate are shorter than in healthy tissue fr...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Chem Lab Med Source Type: research
This study looks at guidance implementation in a UK oncology institution.
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
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