Physiological and pathological characterization of capsaicin ‐induced reversible nerve degeneration and hyperalgesia

ConclusionsThere were differential restoration of IENF density, CHEP and thermal thresholds, and changed CHEP–IENF relationships during skin reinnervation. CHEP can be a physiological signature of acute hyperalgesia.
SignificanceThese observations suggested the relationship between nociceptive nerve terminals and brain responses to thermal stimuli changed during different degree of skin denervation, and CHEP to low‐intensity heat stimulus can reflect the physiology of hyperalgesia.

Source: European Journal of Pain - February 2, 2018 Category: Anesthesiology Authors: H. Chiang, K. ‐C. Chang, H.‐W. Kan, S.‐W. Wu, M.‐T. Tseng, H.‐W. Hsueh, Y.‐H. Lin, C.‐C. Chao, S.‐T. Hsieh Tags: Original Article Source Type: research