The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis

Conclusion: Our results reveal a pathway in which CAL regulates the cell surface availability and intracellular retention of ΔF508 CFTR.Cell Physiol Biochem 2018;45:639 –655

https://www.karger.com/Article/FullText/487120

Source: Cellular Physiology and Biochemistry - February 2, 2018 Category: Cytology Source Type: research