Perspectives Superbugs and us

These days you would have to be peculiarly immune to public health messaging not to know that the world is on the brink of an antibiotic apocalypse. From the back of pill packets to the panels on the back of buses, prompts urging us to “keep antibiotics working” are almost as ubiquitous as the drug-resistant microbes themselves. Although medical experts have been warning about the indiscriminate use of antibiotics since the 1940s, their consumption continues to grow. This is not only a problem in countries like South Africa an d India where antibiotics are widely available over the counter.
Source: LANCET - Category: General Medicine Authors: Tags: Perspectives Source Type: research

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Publication date: Available online 7 December 2018Source: Microbial PathogenesisAuthor(s): João Batista de Andrade Neto, Maria Aparecida Alexandre Josino, Cecília Rocha da Silva, Rosana de Sousa Campos, Francisca Bruna S. Aires do Nascimento, Letícia Serpa Sampaio, Lívia Gurgel do Amaral Valente Sá, Igor de Sá Carneiro, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Jacó Ricarte Lima de Mesquita, Bruno Coelho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre JúniorAbstractEmergence of methicilin resistant Staphylococcus aureus (M...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsThis novel MDP offers a rapid, sensitive, and specific option for pathogen detection in pediatric patients with musculoskeletal infections.
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Abstract We previously showed that a naturally occurring macrocyclic bis(bibenzyl) derivative, riccardin C (RC), exhibits antibacterial activity towards methicillin-resistant Staphylococcus aureus (MRSA), with a potency comparable to that of the clinically used drug vancomycin. Here, we synthesized a series of RC derivatives to explore the structure-activity relationships (SAR). The SAR results clearly indicated that the number and positions of the phenolic hydroxyl groups are primary determinants of the anti-MRSA activity. Pharmacological characterization of the macrocyclic bis(bibenzyl) derivatives, together wit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Conclusions: We found sonication for identification of pathogens could be helpful, but this finding should be interpreted carefully because of the possibility of contamination. Sterilization of an infected femoral implant with an autoclave method could be a good method for using the temporary articulating antibiotic spacer in two-stage revision arthroplasty. PMID: 30505410 [PubMed - in process]
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research
Antibiotic-resistant bacteria cause hospital epidemics and are associated with therapeutic failures and an increased morbidity and mortality [1,2]. Mastering the consumption of antibiotics is a critical point since the link between the use of antibiotics and the emergence of antibiotic resistance has been well established, particularly in intensive care units (ICUs) where broad-spectrum antibiotics are frequently prescribed [3,4]. Especially, quinolones, cephalosporins and carbapenems are said to have a high “ecologic impact”, by favoring the selection of drug-resistant bacteria to both the antibiotic used and ...
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
DISCUSSION: Forty-one percent of children in this multicenter cohort underwent at least one repeat surgical procedure after the index arthrotomy for management of presumed SAH. Risk factors for return to the operating room include elevated initial erythrocyte sedimentation rate and C-reactive protein, infection with MRSA, and presence of osteomyelitis. LEVEL OF EVIDENCE: Level 3, case-cohort series. Type of evidence, therapeutic. PMID: 30520802 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
In conclusion, it was suggested that L. tigrinus can be used as a natural source due to its antioxidant and antimicrobial activities. PMID: 30515206 [PubMed]
Source: Advances in Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
In this study, the authors report the antimicrobial potential of C. absus extracts obtained with different solvents. The extract(s) obtained with ethyl acetate yielded the best antibacterial effects because of a rich supply of oxalates and alkaloids in it. The same extract was also exploited for reducing Ag+ ions (to metallic Ag0) for the synthesis of nanoparticles. Electron microscopy revealed that the silver nanoparticles were ∼18–25 nm in diameter. The Fourier-transform infrared evaluation pointed towards the fact that flavonoids present in the plant extract were acting as reductants while amino groups were ...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Identification of novel sources for developing new antibiotics is imperative with the emergence of antibiotic resistant bacteria. The fruits of Terminalia bellirica (Gaertn) Roxb., widely used in traditional medi...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
Atopic dermatitis (AD) is the most common chronic inflammatory skin condition of childhood. It is associated with allergic co-morbities including asthma and allergic rhinitis. AD patients are also affected by sleep deprivation and psychosocial problems. Those with uncontrolled AD may require hospitalization.1 Previous studies have shown that about 70% of children who were treated inpatient for AD exacerbation were given an antibiotic.2,3 However, information on the choice of antibiotics used to treat AD exacerbation is limited.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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