Perspectives Superbugs and us

These days you would have to be peculiarly immune to public health messaging not to know that the world is on the brink of an antibiotic apocalypse. From the back of pill packets to the panels on the back of buses, prompts urging us to “keep antibiotics working” are almost as ubiquitous as the drug-resistant microbes themselves. Although medical experts have been warning about the indiscriminate use of antibiotics since the 1940s, their consumption continues to grow. This is not only a problem in countries like South Africa an d India where antibiotics are widely available over the counter.
Source: LANCET - Category: General Medicine Authors: Tags: Perspectives Source Type: research

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Antimicrobial resistance (AMR) is one of the greatest threats to human health throughout the world, warns Gary Cohen, executive vice president of global health for BD. “There is an increasing risk of going back to the pre-antibiotic era,” he told MD+DI. “Resistance is not a new issue—it is just a bigger problem, at an accelerated pace. Because antibiotics have been overprescribed for humans as well as overused in food production, antimicrobial resistance is not just a theoretical threat.” Everyone needs to play a role, including diagnostics manufacturers and even medical device innovators, he ...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Conclusions This synergistic action of vitamins with antibiotics may be used as a tool to treat MDR superbugs, with further evaluation required at a molecular level. Graphical abstract
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusions This study showed that ceftaroline and ceftobiprole have excellent in vitro activity against clinical isolates of staphylococci involved in PJIs. These molecules may therefore represent promising alternatives for the treatment of such infections.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Feng-Jui Chen, Tsai-Ling Lauderdale, Chen-Hsiang Lee, Yu-Chieh Hsu, I-Wen Huang, Pei-Chi Hsu, Chung-Shi Yang
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: Our study revealed the present situation of SA colonization in four cities of China using a new method and had reference significance in anti-SA using topical antibiotic. PMID: 29781315 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusions Clonality was found behind the wide distribution of MDR capsular types 19A, 6C, 23A and 3 after vaccine introduction, and a highly multi-resistant and virulent clone Taiwan19F-14/ST320, has emerged as a common pathogen in children.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractBackgroundInfectious disease is the second most common cause of death in patients receiving hemodialysis (HD). When presenting to the emergency department (ED) with fever, it remains a diagnostic challenge to distinguish patients with potentially life-threatening bacterial infections from those with less significant causes of fever. The primary goal of this study was to determine the rate of bacteremia in HD patients presenting to the ED with fever. The secondary goal of this study was to identify any independent risk factors associated with bacteremia in the febrile HD patient.MethodsThis is a retrospective medica...
Source: International Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
l Ryu In response to increasing concern over antibiotic-resistant Staphylococcus aureus, the development of novel antimicrobials has been called for, with bacteriophage endolysins having received considerable attention as alternatives to antibiotics. Most staphylococcal phage endolysins have a modular structure consisting of an N-terminal cysteine, histidine-dependent amidohydrolases/peptidase domain (CHAP), a central amidase domain, and a C-terminal cell wall binding domain (CBD). Despite extensive studies using truncated staphylococcal endolysins, the precise function of the amidase domain has not been determined. He...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: 1 October 2018 Source:Materials Science and Engineering: C, Volume 91 Author(s): Bhaskar Das, Sahoo Moumita, Soumen Ghosh, Md Imran Khan, Dash Indira, R. Jayabalan, Suraj K. Tripathy, Amrita Mishra, P. Balasubramanian Nanobiotechnology has become a newly evolving field of interest in biomedical applications due to its biocompatibility and non-toxic nature towards the environment. Metal and metal oxide nanoparticles have been widely used as an antibacterial agent due to the emergence of antibiotic resistant pathogens, which leads to the outbreak of infectious diseases. In the present paper, biogenic synth...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Authors: Tadesse S, Alemayehu H, Tenna A, Tadesse G, Tessema TS, Shibeshi W, Eguale T Abstract BACKGROUND: Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. METHODS: Wound and ...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
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