World Report Prospects for dementia research
After Pfizer's withdrawal from the market, some predicted a mass exodus of pharmaceutical companies' interests in Alzheimer's disease drug research. Geoff Watts reports.
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Publication date: Available online 26 May 2018 Source:Alzheimer's & Dementia Author(s): Ara S. Khachaturian, Kathleen M. Hayden, Michelle M. Mielke, Yi Tang, Michael W. Lutz, Michael Gold, Walter A. Kukull, Richard Mohs, Serge Gauthier, José Luis Molinuevo, Henrik Zetterberg, Zaven S. Khachaturian
DISCUSSION: PET can evaluate amyloid expansion from cortex to subcortex. Using striatal signal as a marker of advanced amyloidosis may increase predictive power in Alzheimer's dementia research. PMID: 29792874 [PubMed - as supplied by publisher]
DISCUSSION: GBA variants are of great clinical relevance for the development of dementia in Parkinson's disease, especially due to the relatively higher frequency of these alleles compared with other risk alleles. PMID: 29792872 [PubMed - as supplied by publisher]
DISCUSSION: White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population. However, studies are warranted to further determine the role of markers of cerebral small vessel disease in dementia. PMID: 29792871 [PubMed - as supplied by publisher]
This study should be of great interest to anyone that is worried about developing Alzheimer's disease later in life.byAlzheimer's Reading RoomIt should also be of great interest for Alzheimer's caregivers.Researchers at the UCLA Fielding School of Public Health conducted the study to determine risks based on age, gender and biomarker screening.What is the Difference Between Alzheimer ’s and DementiaSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowDuring the past decade, researchers have identifiednew ways to detect the earliest biological signs of Alzheimer ’s disease.These early signs, w...
A person does not die directly from Alzheimer's disease; but instead, from complications caused by Alzheimer's disease.How do you know when a dementia patient is dying?Over time, and as Alzheimer's progresses, the body's immune system weakens, increasing susceptibility to infection and other causes of death related to the elderly.Typical complications from Alzheimer's and related dementia are:heart attacks, strokes, kidney failure, and lung infections due to aspiration of food. Multi-organ failure is often the cause of death in dementia patients.Learn More -Can you die from Alzheimer's disease?By Bob DeMarcoAlzheimer's Rea...
DEMENTIA is a term used to describe different types of brain degeneration. The most common type of dementia is Alzheimer ’s Disease, although vascular dementia and dementia with lewy bodies are also types. Symptoms of dementia include leaving items in the wrong place and memory loss. New research has provided hope for diagnosing dementia early, by finding that people with more yellow spots in their eye are more like ly to have the condition.
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Discussion Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease–related cognitive decline.