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World Report Prospects for dementia research

After Pfizer's withdrawal from the market, some predicted a mass exodus of pharmaceutical companies' interests in Alzheimer's disease drug research. Geoff Watts reports.
Source: LANCET - Category: General Medicine Authors: Tags: World Report Source Type: research

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Publication date: Available online 21 February 2018 Source:Computational and Structural Biotechnology Journal Author(s): Dimitrios Zafeiris, Sergio Rutella, Graham Roy Ball The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. Artificial Neural Networks (ANN) are some of the most commonly used statistical models and have been successful in biomarker discovery studies in multiple disease types. This review seeks to explore and evaluate an integrated ANN pipeline for biomarker discovery and validation in Alzheimer's disease, the most common ...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
AbstractIntracellular β-amyloid (Aβ) accumulation is an early event in Alzheimer’s disease (AD) progression. Recently, it has been uncovered that presenilins (PSs), the key components of the amyloid precursor protein (APP) processing and the β-amyloid producing γ-secretase complex, are highly enriched in a special sub-compartment of the endoplasmic reticulum (ER) functionally connected to mitochondria, called mitochondria-associated ER membrane (MAM). A current hypothesis of pathogenesis of Alzheimer’s diseases (AD) suggests that MAM is involved in the initial phase of AD. Since MAM supplie...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Conclusion: The variable clinical findings associated with the S170F mutation highlight the relevance of atypical phenotypes in the context of research and under a clinical perspective. CSF sampling and detection of A β species may be essential to indicate AD pathology in unclear cases presenting with cognitive and motor symptoms at a younger age.Neurodegener Dis 2018;18:57-68
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
FINDINGSPerforming memory training exercises at the same time as pedaling a stationary bike led to better gains in memory than doing the training exercises after working up a sweat, according to a 55-person study led by UCLA researchers. The findings suggest that exercise may temporarily make it easier for the brain to create new memories.BACKGROUNDIn the United States, studies have shown that more than 40 percent of people over age 60 have some memory decline or forgetfulness; it ’s often considered a normal part of aging. Researchers have previously uncovered a handful of lifestyle interventions — including e...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Authors: Royall DR, Palmer RF Abstract The "δ" (for "dementia") is a latent dementia phenotype that can be constructed by a unique confirmatory bifactor model in a structural equation model framework. Because it is derived from Spearman's general intelligence factor, "g," δ can be constructed from any cognitive battery. This may allow for accurate dementia case-finding by telephone and in the absence of expert clinical evaluation or review. The authors constructed a new δ homolog in a large ethnically diverse convenience sample: the Texas Alzheimer's Research and Care...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
(Natural News) Aerobic exercise, such as taking a brisk walk, each day can help protect the brain from cognitive decline, according to a recent study. In the U.S., approximately 50 million people are suffering from Alzheimer’s disease, the sixth leading cause of death in the country, or other forms of dementia. A team of researchers...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: A relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention.Dement Geriatr Cogn Disord Extra 2018;8:60 –71
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
A study published on 20  February in the Lancet Public Health has suggested that alcohol abuse addiction disorders are a major risk factor for dementia, specifically early onset dementia. 
Source: Alzheimers Society - Category: Geriatrics Source Type: news
In a large-scale study, links between alcohol use disorder and dementia are fleshed out. The relationship is stronger than previously thought.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
(American Geriatrics Society) A team of researchers from Belgium recently studied how people with Alzheimer's disease use medical services during their final months. The goal was to learn more about the best ways to help older adults with dementia at the end of their lives. Their study was published in the Journal of the American Geriatrics Society.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
More News: Alzheimer's | Dementia | General Medicine | Pfizer