'Better screening and new drugs for prostate cancer now'

We have seen prostate cancer death rates rising year on year, from around 3,500 in the mid-1960s to more than 11,800 currently – and now overtaking deaths from breast cancer for the first time.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusions We report an increased risk of EPMs in patients with IPMN, especially for renal cell, prostate, colorectal, and breast cancer.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Authors: Kim GJ, Jo HJ, Lee KJ, Choi JW, An JH Abstract We evaluated oleanolic acid (OA)-induced anti-cancer activity, apoptotic mechanism, cell cycle status, and MAPK kinase signaling in DU145 (prostate cancer), MCF-7 (breast cancer), U87 (human glioblastoma), normal murine liver cell (BNL CL.2) and human foreskin fibroblast cell lines (Hs 68). The IC50 values for OA-induced cytotoxicity were 112.57 in DU145, 132.29 in MCF-7, and 163.60 in U87 cells, respectively. OA did not exhibit toxicity in BNL CL. 2 and Hs 68 cell lines in our experiments. OA, at 100 µg/mL, increased the number of apoptotic cells to 27....
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Draft guidance dubs Perjeta ‘not cost effective’ Related items fromOnMedica NICE fast-tracks approval of new skin cancer treatment New breast cancer drug ‘unaffordable’ for NHS One in 10 children in phase I cancer trials respond to drugs Cancer strategies failed to improve one-year survival Genetic risk model could guide prostate cancer screening
Source: OnMedica Latest News - Category: UK Health Source Type: news
Henrik Franzyk Since cells in solid tumors divide less rapidly than cells in the bone marrow or cells of the immune system, mitotic inhibitors often cause severe side effects when used for treatment of diseases like prostate cancer and breast cancer. One approach to overcome this problem involves attempts at developing drugs based on general cytotoxins, like calicheamicin and thapsigargin, which kill cells at all phases of the cell cycle. However, such toxins can only be used when efficient targeting to the malignant tissue is possible. In the case of thapsigargin, selectivity for tumor-associated cells is achieved b...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractPurposeSuperparamagnetic nanoparticles of iron oxide (SPION) were shown to be non-inferior to standard radioisotope tracer in breast cancer and may be used as an alternative to identify sentinel lymph nodes (SLN). The aim of this study was to assess the feasibility of sentinel lymph node dissection (SLND) using SPION in prostate cancer and to evaluate its diagnostic accuracy.MethodsTwenty patients with intermediate- and high-risk prostate cancer were prospectively enrolled in 2016. After intraprostatic injection of SPION, SLND using magnetometer was performed the following day. Extended pelvic lymph node dissection...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
We describe the syntheses of nine new angucyclinone 6-aza-analogues, achieved through a hetero Diels-Alder reaction between the shikimic acid derivative-azadiene 13, with different naphthoquinones. The cytotoxic activity of the new synthesized compounds and five angucyclinones, previously reported, was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and one non-tumoral cell line, human colon epithelial cells (CCD841 CoN). Our results showed that most 6-azadiene derivatives exhibited significant cytotoxic activities, which was demonstrated by their IC5...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Figueroa CD, Molina L, Bhoola KD, Ehrenfeld P Abstract The kallikrein family comprises tissue kallikrein and 14 kallikrein-related peptidases (KLKs) recognized as a subgroup of secreted trypsin- or chymotrypsin-like serine proteases. KLKs are expressed in many cellular types where they regulate important physiological activities such as semen liquefaction, immune response, neural development, blood pressure, skin desquamation and tooth enamel formation. Tissue kallikrein, the oldest member and kininreleasing enzyme, and KLK3/PSA, a tumor biomarker for prostate cancer are the most prominent components of th...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
In this study, for the very first time waterborne TESP was performed in the presence of MNPs. Neat MNPs were coated and in situ functionalized with amine groups by using thiol-ene chemistry. Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription. Anti-EN2 antibodies were immobilized onto these MNPs by physical adsorption and covalent bonding methods, respectively. The amount of the physically immobilized antibodies (0.54 mg/g) were foun...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Concerns expressed that opportunities to save lives may be missedCancer patients in the UK may not receive enough follow-up after a diagnosis, a new study by researchers in Chicago suggests.The study, presented at the annual American Society of Clinical Oncology in Chicago, suggests five years of monitoring is insufficient for some cancers and too long for others. The research suggests some NHS patients may receive too few years of follow-up care.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Cancer Cancer research Breast cancer Bowel cancer Cervical cancer Lung cancer Ovarian cancer Pancreas cancer Prostate cancer Health Medical research Science Society UK news Source Type: news
Cancer is one of the leading causes of death among Americans. At least 10 percent of cancers are caused by inherited mutations in genes such as BRCA1 and BRCA2. Parents with the cancer gene mutation have a 50 percent chance of passing it on to a son or daughter. It ’s well-known that women with BRCA are at a very high risk for breast and ovarian cancer. Less known is the fact that men with these mutations also are at risk of breast cancer and other cancers.Astudy published in April in JAMA Oncology finds that few men are screened for these genetic mutations — and the researchers strongly suggest that they be sc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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