Pre- and Early Post-Transplant Spirometric Parameters are Associated with the Development of Bronchiolitis Obliterans Syndrome after Allogeneic HCT

Background: Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant (HCT), a manifestation of chronic graft-versus-host disease, may occur insidiously and remain asymptomatic until significant loss of lung function has occurred. Early diagnosis and intervention are needed to prevent the morbidity and mortality associated with BOS, however screening strategies such as frequent spirometry are difficult to universally implement. The aim of this study was to assess which readily available clinical factors, with an emphasis on pulmonary function test (PFT) parameters, can identify patients at risk for developing BOS in the first 3 months after HCT.

Source: Biology of Blood and Marrow Transplantation - February 1, 2018 Category: Hematology Authors: Kareem Jamani, Chad He, Yang Liu, Jesse Hubbard, Mary E. Flowers, Ted Alan Gooley, Guang-Shing Cheng Source Type: research