Bone Marrow Fibrosis Assessed by Computer-Assisted Image Analysis (CIA) is Associated with Poor Risk Cytogenetics and Lower Overall Survival after Allogeneic HSCT for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Background: There are very limited data on the impact of BM fibrosis on prognosis and survival of AML and MDS especially after allogeneic HSCT. The current system of Reticulin Score for grading fibrosis according to (WHO 2008) is only semi-quantitative and subject to inter-observer inconsistency and no performance data. We evaluated BM fibrosis by a new objective and highly quantitative method of Computer-assisted Image Analysis (CIA) and correlated it to cytogenetics, survival and treatment-related mortality after allo-sib HSCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research