Association of Dlco, Age and HLA Matching with Hematopoietic Stem Cell Transplantation in Patients with AML and MDS

Background: Allogeneic hematopoietic stem cell transplantation (HCT) is a highly effective therapy for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), but can be associated with significant morbidity and mortality. Low pre-HCT diffusing capacity for carbon monoxide (DLCO) is a risk factor for death post-HCT. We sought to identify additional patient- or HCT-related variables that might modulate this risk.

Source: Biology of Blood and Marrow Transplantation - February 1, 2018 Category: Hematology Authors: Alexander Geyer, Molly Maloy, Patrick Hilden, Ann A. Jakubowski Source Type: research