Association of Dlco, Age and HLA Matching with Hematopoietic Stem Cell Transplantation in Patients with AML and MDS

Background: Allogeneic hematopoietic stem cell transplantation (HCT) is a highly effective therapy for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), but can be associated with significant morbidity and mortality. Low pre-HCT diffusing capacity for carbon monoxide (DLCO) is a risk factor for death post-HCT. We sought to identify additional patient- or HCT-related variables that might modulate this risk.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Publication date: Available online 8 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): R. PranavKumar Shadamarshan, Harini Balaji, Harsha Shrihari Rao, K. Balagangadharan, S. Viji Chandran, N. SelvamuruganAbstractTrans-anethole (TA) is a phenolic phytocompound widely used in the food and health sector because of its diverse biological properties. However, its role in the promotion of bone formation is not known. With the enhanced bioavailability of TA, we aimed to determine its effect on osteogenesis; TA at different concentrations (5, 10, and 20 µM) was loaded onto polycaprolactone (PCL)/polyvinylp...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Conclusion: IdeS may represent a groundbreaking new method of desensitization for patients who otherwise might have no hope for receiving a lifesaving transplant.
Source: Annals of Surgery - Category: Surgery Tags: Papers of the 138Th ASA Annual Meeting Source Type: research
Publication date: Available online 13 August 2018Source: The Lancet HaematologyAuthor(s): Tapan M Kadia, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Marina Konopleva, Christopher B Benton, Jan Burger, Koji Sasaki, Gautam Borthakur, Courtney D DiNardo, Naveen Pemmaraju, Naval Daver, Alessandra Ferrajoli, Xuemei Wang, Keyur Patel, Jeffrey L Jorgensen, Sa Wang, Susan O'Brien, Sherry Pierce, Carla TuttleSummaryBackgroundFront-line therapy for elderly or unfit patients with acute myeloid leukaemia (AML) remains unsatisfactory with poor outcomes and excessive toxicity. We studied a new low-intensity regimen of cladribine combin...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: September 2018Source: Archives of Cardiovascular Diseases Supplements, Volume 10, Issues 3–4Author(s): Yasmine Benadjaoud, Fanny Bajolle, Olivier Raisky, Damien BonnetObjectiveSingle-ventricular disease with atrioventricular septal defect (AVSD) includes a variety of complex congenital heart defects such as unbalanced AVSD and univentricular hearts with common atrioventricular valve, commonly associated with heterotaxy. Our objective was to describe hard outcomes (death, transplantation) and their predictors in these defects.MethodsWe conducted a retrospective, monocentric review of children with a ...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: September 2018Source: Archives of Cardiovascular Diseases Supplements, Volume 10, Issues 3–4Author(s): Zahra Belhadjer, Diala Khraich, Damien BonnetIntroductionThe dilated cardiomyopathies (DCM) in pediatric patients is a severe disease and is the leading cause of heart transplantation in children. Predictive factors for mortality and transplantation differs from one study to another with a lack of long-term data. The aim of this study is to determine these factors during the follow-up.MethodsWe performed a retrospective monocentric study of patients followed up for DCM. Patients under the age of 18...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionIncidental findings are common but the majority are of no clinical consequence. No additional cancers were noted in our series. DWI and CE T1-W sequences increased diagnostic confidence in 50% of indeterminate findings; and may reduce the need for further investigation.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader, Eva Herrmann, Ulrike Koehl
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 August 2018Source: Stem Cell ResearchAuthor(s): Deepak Kumar, Ashaq Hussain, Achal K. Srivastava, Mitali Mukerji, Odity Mukherjee, Mohammed FaruqAbstractSpinocerebellar ataxia type-12 (SCA12) is a neurological disorder caused due to triplet (CAG) repeat expansion in 5' UTR of PPP2R2B. It is one of the most prominent SCA-subtype in Indian population and till date no patient specific models have been described. Human-induced-pluripotent-stem cell (HiPSC) based disease modelling has become the next generation tool for studying various human pathologies. In the present study we established...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 13 August 2018Source: Stem Cell ResearchAuthor(s): Sonia Sanz Muñoz, Rachelle Balez, Mauricio e Castro Cabral-da-Silva, Tracey Berg, Martin Engel, Monique Bax, Dzung Do-Ha, Claire H. Stevens, Mark Greenough, Ashley Bush, Lezanne OoiAbstractThe induced pluripotent stem cell (iPSC) lines UOWi002-A and UOWi003-A were reprogrammed from dermal fibroblasts via mRNA transfection. Dermal fibroblasts from a 56 year old female caucasian familial Alzheimer's disease patient carrying A246E mutation in the PSEN1 gene (familial AD3, autopsy confirmed Alzheimer's disease) and a 75 year old fe...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Controlling graft-versus-host disease (GVHD) remains a major unmet need in stem cell transplantation, and new, targeted therapies are being actively developed. CD28-CD80/86 costimulation blockade represents a promising strategy, but targeting CD80/CD86 with CTLA4-Ig may be associated with undesired blockade of coinhibitory pathways. In contrast, targeted blockade of CD28 exclusively inhibits T cell costimulation and may more potently prevent GVHD. Here, we investigated FR104, an antagonistic CD28-specific pegylated-Fab′, in the nonhuman primate (NHP) GVHD model and completed a multiparameter interrogation comparing i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Biology | Carbon Monoxide Poisoning | Leukemia | Myelodysplastic Syndrome | Stem Cell Therapy | Stem Cells | Transplants