Association of Dlco, Age and HLA Matching with Hematopoietic Stem Cell Transplantation in Patients with AML and MDS

Background: Allogeneic hematopoietic stem cell transplantation (HCT) is a highly effective therapy for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), but can be associated with significant morbidity and mortality. Low pre-HCT diffusing capacity for carbon monoxide (DLCO) is a risk factor for death post-HCT. We sought to identify additional patient- or HCT-related variables that might modulate this risk.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Conclusion: This genome-scale single nucleotide resolution analysis of DNA methylation in human polycystic kidneys suggests that DNA methylation differences at specific loci are associated with ADPKD. Further exploration into the significance of these preliminary results may shed light on the disease process, and potentially reveal new therapeutic possibilities.Am J Nephrol 2018;48:415 –424
Source: American Journal of Nephrology - Category: Neurology Source Type: research
We describe clinical and laboratory features, bone marrow pathology, treatment, and overall outcome.Acta Haematol 2019;141:23 –27
Source: Acta Haematologica - Category: Hematology Source Type: research
I have long argued that reduction in average telomere length with age is a downstream measure of aging, not an upstream cause of aging. Telomeres are the caps of repeated DNA sequences found at the end of chromosomes. A little is lost with each cell division, and when telomeres get too short then the cell become senescent and is destroyed. This mechanism limits the number of times a cell can replicate. The vast majority of our cells are somatic cells that are limited in this way. A tiny number of stem cells can maintain lengthy telomeres via use of the telomerase enzyme and thus divide indefinitely. This is how near all mu...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Use of kidneys from deceased donors with acute kidney injury appears safe in multiyear follow-up and could make many more organs available for transplant, a multicenter study has found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
Publication date: Available online 20 November 2018Source: Canadian Journal of CardiologyAuthor(s): Bobby Yanagawa, Subodh Verma, Girish Dwivedi, Marc RuelAbstractThe clinical status of human immunodeficiency virus (HIV) infection has changed dramatically with the introduction of combined antiretroviral therapy (cART). Patients with HIV are now living long enough to be susceptible to chronic illnesses, such as coronary disease and non-ischemic cardiomyopathy, which can be consequences of the cART treatment itself. Cardiovascular diseases are a major source of morbidity and mortality in HIV-positive patients. Increasingly, ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsOur findings illustrate that constitutional rearrangements can mimic recurrent genetic abnormalities observed in AML, and we emphasize the importance of correlating genetic data with clinical and hematopathologic information.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
This report brings attention to an emerging mycosis of community-acquired Exophiala species infection in the very-late phase after allogenic HSCT in patients with chronic GVHD. PMID: 30449799 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Okuni M, Yakushijin K, Uehara K, Ichikawa H, Suto H, Hashimoto A, Tanaka Y, Shinzato I, Sakai R, Mizutani Y, Nagao S, Kurata K, Kakiuchi S, Miyata Y, Inui Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Matsuoka H, Minami H Abstract A 45-year-old woman was diagnosed with hepatosplenic T-cell lymphoma (HSTCL), a rare subtype of peripheral T-cell lymphoma. She received different types of chemotherapy, but disease progression was observed. To reduce the tumor burden before an unrelated bone marrow transplantation, combination chemotherapy consisting of the gemcitabine, carboplatin, and dexamethasone (GCD) was admi...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Yamauchi R, Takata K, Shinagawa Y, Tanaka T, Fukuda H, Fukuda S, Kunimoto H, Umeda K, Morihara D, Yokoyama K, Takeyama Y, Irie M, Shakado S, Mizoguchi M, Hisano S, Yoshimitsu K, Sakisaka S Abstract A 70-year-old man was admitted for treatment of a single liver nodule that was detected by contrast-enhanced computed tomography. Twenty years earlier, the patient had been diagnosed with myelodysplastic syndrome-refractory anemia and secondary hemochromatosis but had not received erythrocyte transfusions. The current histological, computed tomography, and magnetic resonance imaging findings revealed hepatocellu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 20 November 2018Source: Stem Cell ResearchAuthor(s): T.V. Nikitina, A.G. Menzorov, A.A. Kashevarova, M.M. Gridina, A.A. Khabarova, S. Yakovleva Yu, M.E. Lopatkina, I.E. Pristyazhnyuk, S.A. Vasilyev, O.L. Serov, I.N. LebedevAbstractSkin fibroblasts from a patient with neurodevelopmental and speech delay, anxiety disorder, macrocephaly, microorchidism, multiple anomalies of internal organs and ring chromosome 13 were reprogrammed into induced pluripotent stem cells (iPSCs) to generate a clonal stem cell line IMGTi003-A (iTAF6-6). IMGTi003-A pluripotency was demonstrated by three germ layer ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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