Impact of Xylitol on Oral Microbiome and Blood Stream Infections in HSCT Recipients

Background: Blood stream infections in patients with central venous catheters may arise from translocation of bacteria through a non-intact mucosa. These infections are known as mucosal barrier injury –laboratory confirmed blood stream infections (MBI-LCBI). Currently there are no proven strategies to prevent bacteremia secondary to mucosal barrier injury after hematopoietic stem cell transplant (HSCT). Xylitol is a non-fermentable sugar alcohol that reduces dental caries, plaque accumulation, and oral disease progression by inhibiting bacterial growth and reducing pathogenic community development.

Source: Biology of Blood and Marrow Transplantation - February 1, 2018 Category: Hematology Authors: Priscila Badia, Heidi Andersen, David Haslam, Adam S. Nelson, Javier El-Bietar, Abigail R. Pate, Sara Golkari, Ashley Teusink-Cross, Laura Flesch, Ashely Bedel, Victoria Hickey, Kathi Kramer, Stella M. Davies, Sarat Thikkurissy, Christopher E. Dandoy Source Type: research