Pharmacokinetics and Toxicities after Evomela ® (Propylene Glycol Free Melphalan) with Hematopoietic Stem Cell Transplant (HCT) for Multiple Myeloma (MM), AL Amyloidosis (AL), Lymphoma, Acute Myeloid Leukemia (AML), and Myelodysplastic Syndrome (MDS)

Background: Melphalan exposure as measured by area under the curve (AUC) has a 5-fold variability between pts, with higher AUCs associated with improved outcomes but increased toxicity (Shaw BBMT 2012). Evomela ® (propylene glycol free melphalan, PGF-MEL) is an intravenous formulation with improved stability and possibly less toxicity related to the solubilizing agent. We aimed to determine the pharmacokinetics (PK) and relationship between exposure and toxicities with this formulation in order to optimiz e dosing.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Publication date: Available online 8 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): R. PranavKumar Shadamarshan, Harini Balaji, Harsha Shrihari Rao, K. Balagangadharan, S. Viji Chandran, N. SelvamuruganAbstractTrans-anethole (TA) is a phenolic phytocompound widely used in the food and health sector because of its diverse biological properties. However, its role in the promotion of bone formation is not known. With the enhanced bioavailability of TA, we aimed to determine its effect on osteogenesis; TA at different concentrations (5, 10, and 20 µM) was loaded onto polycaprolactone (PCL)/polyvinylp...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Th érèse Coffey’s ill-judged tweet shows we have still work to do to rid the planet of the glyphosateOn a summer Sunday afternoon, Th érèse Coffey, parliamentary-under secretary of state at the Department for Environment, Food and Rural Affairs (Defra), was, it would appear from her Twitter feed, about to do some gardening. Unremarkable, you might think. Parliament is in recess, and parliamentarians are entitled to their leisure like anyone else.But this was political gardening, for before doing so she put out a quite remarkable message: “Getting ready to deploy the amazing Roundup!&...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Monsanto Pesticides Bayer Agriculture Farming Conservatives Food safety Environment European Union Science Politics Source Type: news
Conclusion: IdeS may represent a groundbreaking new method of desensitization for patients who otherwise might have no hope for receiving a lifesaving transplant.
Source: Annals of Surgery - Category: Surgery Tags: Papers of the 138Th ASA Annual Meeting Source Type: research
Publication date: Available online 13 August 2018Source: The Lancet HaematologyAuthor(s): Tapan M Kadia, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Marina Konopleva, Christopher B Benton, Jan Burger, Koji Sasaki, Gautam Borthakur, Courtney D DiNardo, Naveen Pemmaraju, Naval Daver, Alessandra Ferrajoli, Xuemei Wang, Keyur Patel, Jeffrey L Jorgensen, Sa Wang, Susan O'Brien, Sherry Pierce, Carla TuttleSummaryBackgroundFront-line therapy for elderly or unfit patients with acute myeloid leukaemia (AML) remains unsatisfactory with poor outcomes and excessive toxicity. We studied a new low-intensity regimen of cladribine combin...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: September 2018Source: Archives of Cardiovascular Diseases Supplements, Volume 10, Issues 3–4Author(s): Yasmine Benadjaoud, Fanny Bajolle, Olivier Raisky, Damien BonnetObjectiveSingle-ventricular disease with atrioventricular septal defect (AVSD) includes a variety of complex congenital heart defects such as unbalanced AVSD and univentricular hearts with common atrioventricular valve, commonly associated with heterotaxy. Our objective was to describe hard outcomes (death, transplantation) and their predictors in these defects.MethodsWe conducted a retrospective, monocentric review of children with a ...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: September 2018Source: Archives of Cardiovascular Diseases Supplements, Volume 10, Issues 3–4Author(s): Zahra Belhadjer, Diala Khraich, Damien BonnetIntroductionThe dilated cardiomyopathies (DCM) in pediatric patients is a severe disease and is the leading cause of heart transplantation in children. Predictive factors for mortality and transplantation differs from one study to another with a lack of long-term data. The aim of this study is to determine these factors during the follow-up.MethodsWe performed a retrospective monocentric study of patients followed up for DCM. Patients under the age of 18...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionIncidental findings are common but the majority are of no clinical consequence. No additional cancers were noted in our series. DWI and CE T1-W sequences increased diagnostic confidence in 50% of indeterminate findings; and may reduce the need for further investigation.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader, Eva Herrmann, Ulrike Koehl
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 August 2018Source: Stem Cell ResearchAuthor(s): Deepak Kumar, Ashaq Hussain, Achal K. Srivastava, Mitali Mukerji, Odity Mukherjee, Mohammed FaruqAbstractSpinocerebellar ataxia type-12 (SCA12) is a neurological disorder caused due to triplet (CAG) repeat expansion in 5' UTR of PPP2R2B. It is one of the most prominent SCA-subtype in Indian population and till date no patient specific models have been described. Human-induced-pluripotent-stem cell (HiPSC) based disease modelling has become the next generation tool for studying various human pathologies. In the present study we established...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 13 August 2018Source: Stem Cell ResearchAuthor(s): Sonia Sanz Muñoz, Rachelle Balez, Mauricio e Castro Cabral-da-Silva, Tracey Berg, Martin Engel, Monique Bax, Dzung Do-Ha, Claire H. Stevens, Mark Greenough, Ashley Bush, Lezanne OoiAbstractThe induced pluripotent stem cell (iPSC) lines UOWi002-A and UOWi003-A were reprogrammed from dermal fibroblasts via mRNA transfection. Dermal fibroblasts from a 56 year old female caucasian familial Alzheimer's disease patient carrying A246E mutation in the PSEN1 gene (familial AD3, autopsy confirmed Alzheimer's disease) and a 75 year old fe...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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