Mechanistic enzymology in drug discovery: a fresh perspective

Nature Reviews Drug Discovery 17, 115 (2018).
doi:10.1038/nrd.2017.219

Authors: Geoffrey A. Holdgate, Thomas D. Meek & Rachel L. Grimley
Given the therapeutic and commercial success of small-molecule enzyme inhibitors, as exemplified by kinase inhibitors in oncology, a major focus of current drug-discovery and development efforts is on enzyme targets. Understanding the course of an enzyme-catalysed reaction can help to conceptualize different types of inhibitor

Source: Nature Reviews Drug Discovery - December 1, 2017 Category: Drugs & Pharmacology Authors: Geoffrey A. Holdgate Thomas D. Meek Rachel L. Grimley Tags: Review Source Type: research