Effective Vortioxetine Dose Varies with Extent of Antidepressant Use Across Countries.

Conclusions: In countries with high antidepressant utilization, higher doses of vortioxetine were required, and obverse was true in countries with lower antidepressant utilization. These data support the hypothesis that tolerance to serotonin reuptake inhibition drives poor antidepressant response.
PMID: 29382958 [PubMed - in process]

Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research