Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats

Conclusion These results suggest that ICS II attenuates IBO-induced cognitive deficits, possibly via the regulation of calbindin expression and inhibition of apoptotic response, and the MAPK signaling pathway is implicated in the potential mechanisms of ICS II against IBO-induced excitotoxicity, indicating that ICS II is a promising compound for treatment of excitotoxicity-related diseases, including AD. Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research