Clinical oral dryness score: evaluation of a new screening method for oral dryness
Odontology pp 1 –6 |Cite asAbstractThe purpose of this study was to explore the association of the clinical oral dryness score (CODS) with salivary flow rates, xerostomia inventory (XI), and bother index (BI). 147 patients were screened using CODS, which determined 10 features of oral dryness. Each feature contributed 1 point, and the total score varied from 0 to 10. Unstimulated (UWS), chewing-stimulated (CH-SWS) and acid-stimulated (A-SWS) whole salivary flows and the XI and BI were measured. Associations were explored with a bootstrapped Spearman rank correlation test (1000 × bootstrapping). Based on unstimulated salivary flow, 55 patients were classified as hyposalivators, 31 as low salivators, 48 as normosalivators and 13 as high salivators. Median CODS in the hyposalivation group was 5 (IQR 3 –6) compared with 3 (IQR 2–5) in the low salivation group, 2 (IQR 1–4) in the normal salivation group and 2 (IQR 1–2.5) in the high salivation group. Significant associations between CODS and the other parameters were only found in the hyposalivation group between CODS and UWS (ρ(53) = − 0.513;p
ConclusionsAdaptive two-step IMRT for NPC demonstrated an excellent 3-year OS with acceptable toxicities. This method may be one treatment option for locally advanced NPC.
In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients.MethodThe data of 352 pSS patients were analyzed retrospectively. The patients were divided into two groups as those with the onset age of 35 or younger (early-onset) and those with the onset age of older than 35. The clinical, laboratory, and serological characteristics of the two groups were compared.p
Conditions: Xerostomia; Hyposalivation Intervention: Device: Biotene® Oralbalance Moisturizing Gel Sponsors: Nova Scotia Health Authority; Dalhousie University Not yet recruiting
Abstract The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750-1,000 ml of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycopr...
This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years (SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years (SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical ev...
Xerostomia, dry mouth, is one of the most common complications during and after radiotherapy for head and neck cancers due to terminal damage to the salivary glands. Xerostomia often contributes to both minor and serious health problems, which severely decrease quality of life for patients. Current methods of management and preventative measures of xerostomia have shown little success and effectiveness. Like all tissues, salivary glands are maintained by a small group of cells, stem/progenitor cells, with the capacity to repopulate and differentiate into the needed cell types upon tissue injury.
To determine whether the radiation (RT) dose to the parotid gland stem cell (SC) region or pre- and mid-treatment CT scans as well as change in parotid gland volume is associated with long-term patient-reported xerostomia after definitive head and neck cancer (HNC) RT.
Salivary gland hypofunction and xerostomia remain major obstacles after radiation of head and neck cancers. There is large unmet need for new treatment strategies as only insufficient symptomatic therapies exits. The randomized controlled MESRIX-trial indicates that autologous adipose-derived mesenchymal stem/stromal cells (ASCs) can safely restore function of the irradiated submandibular glands in former oropharynx cancer patients. Allogeneic ASCs from healthy donors as a ready-to-use therapies have been proved safe for several diseases and may be a new intervention for radiation-induced xerostomia.
CONCLUSIONS: The genital disorders secondary to SS can strongly alter the quality of female life both physically and psychologically as they alter sexuality. However, the observation of certain behavioral norms and the use of appropriate local substances can alleviate the symptoms and effectively contribute to reducing the discomfort. PMID: 32153164 [PubMed - in process]
Abstract This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients. A systematic literature review was performed to retrieve NTCP models for HNC toxicities. Patient population characteristics, NTCP model and the predictors, treatment technique and endpoint definition were extracted per article. Models were then scored based on the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) consensus guidelines to evaluate their generalizability. 335 articles on photon...