Relationship between Hippocampal Subfields and Category Cued Recall in AD and PDD: A Multimodal MRI Study

Publication date: 10 February 2018 Source:Neuroscience, Volume 371 Author(s): Fabiana Novellino, Roberta Vasta, Alessia Sarica, Carmelina Chiriaco, Maria Salsone, Maurizio Morelli, Gennarina Arabia, Valeria Saccà, Giuseppe Nicoletti, Aldo Quattrone Alzheimer’s disease (AD) and Parkinson’s disease with dementia (PDD) are characterized by a different mnesic failure, particularly in memory cued recall. Although hippocampal involvement has been shown in both these diseases, it remains unknown whether a selective damage of specific subfields within the hippocampus may be responsible for the peculiar mnesic profile observed in AD and PDD. To explore this topic, we combined a multimodal 3 T-MRI hippocampal evaluation (whole-brain T1-weighted and diffusion tensor imaging) with a hippocampal-targeted neuropsychological assessment (Free and Cued Selective Reminding Test [FCSRT]) in 22 AD subjects, 18 PDD and 17 healthy controls. Macro- and microstructural features (volume; shape; mean diffusivity [MD]; fractional anisotropy [FA]) of bilateral hippocampi (whole and subfields) were obtained. Correlations between MRI-derived parameters and neuropsychological evaluations were performed. In the comparison between AD and PDD, the multimodal analysis allowed us to identify that subiculum, CA1 and CA4-DG were differently involved in these diseases and correlated with immediate and delayed total recall items of FCSRT. Moreover, compared to controls, AD showed a reduction in a...

Source: Neuroscience - January 31, 2018 Category: Neuroscience Source Type: research