Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy

Conclusion The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis.These findings might partly explain the mechanisms underlying gouty nephropathy.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research