Lancet: Cancer survival rates improve but vary widely
While cancer survival rates are generally increasing worldwide, there are still...Read more on AuntMinnie.comRelated Reading: Cancer deaths continue to fall, but CT lung screening lags Colorectal cancer mortality starts edging back up CDC: Cancer screening lags goals ACS: U.S. cancer death rates continue to fall JAMA: Cancer deaths fall 20% in U.S. since 1980
Abstract The tissue engineering method of decellularization and recellularization has been successfully used in a variety of regenerative medicine applications. The protocols used to de/recellularize various organs and tissues are largely different. Here we describe a method to effectively engineer a bioartificial colon by completely removing original cells from human intestinal tissues followed by repopulating the acellular tissue matrix with cell cultures. This method provides a novel approach for human intestinal regeneration and can be used to identify potential cancer driver genes. PMID: 30542993 [PubMed - in process]
We examined a national cohort of stage IV CRC patients to determine the factors associated with palliative treatment.MethodsStage IV CRC patients, classified based on their survival length (
Conclusion: Low skeletal muscle mass is a negative factor for survival outcomes in mCRC patients treated with salvage-line chemotherapy.Digestion 2019;99:79 –85
Background: Liquid biopsy is a collective term that refers to the analysis of tumor-derived biomarkers isolated from biological fluids of cancer patients. Recently, many authors reported the usefulness of liquid biopsy for the management of malignancy.Summary and Key Messages: The peripheral blood of cancer patients is a pool of cells and/or cell products derived from the primary or metastatic tumor, including circulating tumor cells (CTCs), circulating free (cf) DNA or RNA, and exosomes containing proteins, nucleic acids, and lipids. CTCs are tumor cells that can be isolated from peripheral blood. Free circulating DNA wit...
ConclusionThese findings indicated that CRNDE functions as an oncogene that exerts important regulatory roles in NSCLC progression via sponging miR-338-3p.
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No abstract available
Conditions: Complication; Quality of Life; Surgical Procedure, Unspecified; Lymph Node Metastases; Circulating Tumor Cell Interventions: Procedure: Open surgery; Procedure: Right colectomy; Procedure: Laparoscopic surgery; Procedure: Central lymphadenectomy and vascular ligation Sponsors: Haraldsplass Deaconess Hospital; Helse-Bergen HF; University of Bergen Recruiting
Conditions: Colorectal Cancer Metastatic; Triple Negative Breast Cancer; Non Small Cell Lung Cancer; Bladder Cancer; GastroEsophageal Cancer; Renal Cell Carcinoma; MSI-H Interventions: Biological: EDP1503; Biological: Pembrolizumab Sponsors: Evelo Biosciences, Inc.; SCRI Development Innovations, LLC; Merck Sharp & Dohme Corp. Not yet recruiting
Abstract Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Methods: A systematic search was performed through the PubMed, Web of Science, Embase, and Cochrane library databases to collect eligible studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate the ...