Copy number profiling of oncogenes in ductal carcinoma in situ of the male breast

In conclusion, male DCIS and IC showed a similar copy number profile for 21 out of 22 interrogated BC-related genes, illustrating their clonal relation and the genetically advanced state of male DCIS. MTDH showed a higher copy number ratio in IC compared to adjacent and pure DCIS and may therefore play a role in male breast carcinogenesis. Differences were detected between male and female DCIS for 4 genes pointing to differences in breast carcinogenesis between the sexes.

Source: Endocrine-Related Cancer - January 31, 2018 Category: Endocrinology Authors: Vermeulen, M. A., Doebar, S. C., van Deurzen, C. H. M., Martens, J. W. M., van Diest, P. J., Moelans, C. B. Tags: Research Source Type: research