Shutdown of Claritas Genomics Comes as a Surprise to Lab Community

The recent shutdown ofClaritas Genomics came as a surprise to many lab professionals with some reports making reference to the possibility that inadequate reimbursement for genetic testing may have been the root cause (see:Sudden Shutdown of Claritas Genomics After Five Years as A Leading Source of Pediatric Genetic Testing..) Below is an excerpt from the article:[The shutdown of Claritas may be] the latest market sign of how health insurers are making it difficult for labs to get paid for proprietary molecular diagnostic assays and genetic tests....Claritas was like other genetic testing laboratories... that have long struggled to get health insurers to pay for rare disease tests. Also, Claritas and other genetic and molecular testing labs suffer financially as a direct result of the ongoing price wars among competing genetic testing lab companies....The testing lab combined low false-positive rates with interpretations fromWuXi NextCode. The clinical expertise available at...[Boston Children's Hospital] gave Claritas the best diagnostic exome in the industry in terms of technical quality and diagnostic power....The decision to close the company, the source noted, was a result of misalignment between investors at WuXi NextCode and BCH. Other sources speculated that Claritas and WuXi NextCode were considering a merger, which did not happen....Ultimately, the source stated, BCH held the controlling interest and made the business decision to close the clinica...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Food and Drug Administration Genomic Testing Lab Industry Trends Lab Regulation Medical Consumerism Medical Research Public Health Source Type: blogs

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Authors: Mulak A Abstract Introduction: A growing body of evidence indicates that neuroendocrine interactions may occur at all levels of the brain-gut-microbiota axis, which is directly involved in the pathogenesis of Parkinson's disease (PD).Areas covered: The review presents some current and emerging concepts regarding the organization and functioning of the neuroendocrine system as well as the role of neuroendocrine disturbances in the pathophysiology and symptomatology of PD. The concept of the brain-gut-microbiota triad interactions in the neuroendocrine system and PD is proposed. In PD, dysregulation of the main...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Publication date: Available online 12 December 2019Source: Autoimmunity ReviewsAuthor(s): Ruth Percik, Gadi Shlomai, Amir Tirosh, Amit Tirosh, Raya Leibowitz-Amit, Yael Eshet, Gahl Greenberg, Alex Merlinsky, Ehud Barhod, Yael Steinberg-Silman, Tal SellaAbstractObjectiveImmune checkpoint inhibitors have introduced a new and heterogeneous class of immune-related adverse effects, with the endocrine system being a predominant target for autoimmunity. Autoimmune hypothalamic-pituitary-adrenal axis (HPA) diseases induced by checkpoint inhibitors are being increasingly recognized. We aimed to characterize the spectrum of checkpoi...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionAddressing the challenging classification of CN vs. EMCI provides useful information to help clinicians and researchers determine essential measures that can help in the early detection of AD.Graphical abstract
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 12 December 2019Source: Journal of Neuroscience MethodsAuthor(s): Krishnashis Chatterjee, Cora M Esparza, Jennifer M MunsonAbstractThe brain consists of a complex network of cells and matrix that is kept cushioned and nourished by multiple types of fluids: cerebrospinal fluid, blood, and interstitial fluid. The movement of these fluids through the tissues has recently gained more attention due to implications in Alzheimer's Disease and glioblastoma. Therefore, methods to study these fluid flows are necessary and timely for the current study of neuroscience. Imaging modalities such as magn...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
ConclusionsOur findings contribute to reveal that the relationship between height and weight is strongly related to frontal cognitive dysfunctions in PD patients.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Corrigendum to "Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease". Parkinsons Dis. 2019;2019:2654204 Authors: Tsai ST, Chen TY, Lin SH, Chen SY Abstract [This corrects the article DOI: 10.1155/2019/5676345.]. PMID: 31827761 [PubMed - in process]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conclusion: Nanosomal docetaxel lipid suspension-based chemotherapy was efficacious and well tolerated in the treatment of sarcoma. Further prospective trials are needed to confirm the data. PMID: 31827370 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Pfizer Inc said on Friday the European Medicines Agency granted the company a positive recommendation for approval of its treatment for a rare disorder that occurs in patients with cardiomyopathy.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 12 December 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Sabahuddin Ahmad, Sudha Bhagwati, Sushil Kumar, Dibyendu Banerjee, Mohammad Imran SiddiqiAbstractCathepsin S (CatS) is one of the cysteinyl cathepsins widely studied for its clinical significance and found to be a promising therapeutic target for several diseases; to name a few is arthritis, allergic inflammation, cancer, diabetes, obesity, and cystic fibrosis. Elevated CatS level is a contributing factor for related disorders, and therefore among different strategies to regulate the activity of CatS, one is to ...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Authors: Igboanugo S, Chen A, Mielke JG Abstract Birth asphyxia (BA) affects millions of newborns annually, especially in low-resource communities. Given that much of the attention to this point has focussed upon secondary prevention, we sought to inform the development of primary prevention strategies for BA in resource-limited settings by identifying maternal risk factors. To this end, we systematically reviewed the MEDLINE, PsychInfo, and EMBASE databases, and identified 38 relevant studies. Upon analysis, we found 12 maternal variables associated with BA, and thematically arranged them into 3 categories: sociod...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
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