The Definition of Open Reading Frame Revisited

Publication date: Available online 30 January 2018 Source:Trends in Genetics Author(s): Patricia Sieber, Matthias Platzer, Stefan Schuster The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research