Corbus Cystic Fibrosis Drug to Get FDA Review on Flare-up Data Corbus Cystic Fibrosis Drug to Get FDA Review on Flare-up Data

Corbus Pharmaceuticals Holdings Inc said on Monday the U.S. Food and Drug Administration will evaluate its experimental cystic fibrosis drug without requiring proof the product improves lung function, dramatically cutting the time and cost it will take Corbus to develop the drug.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

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Publication date: Available online 15 January 2019Source: The Lancet Respiratory MedicineAuthor(s): Charles S Haworth, Diana Bilton, James D Chalmers, Angela M Davis, Juergen Froehlich, Igor Gonda, Bruce Thompson, Adam Wanner, Anne E O'DonnellSummaryBackgroundIn patients with non-cystic fibrosis bronchiectasis, lung infection with Pseudomonas aeruginosa is associated with frequent pulmonary exacerbations and admission to hospital for treatment, reduced quality of life, and increased mortality. Although inhaled antibiotics are conditionally recommended for long-term management of non-cystic fibrosis bronchiectasis with freq...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Conclusion:Current limitations of UTE MRI include long scan times, poor delineation of thin-walled structures (e.g. cysts and reticulation) due to limited spatial resolution, low signal to noise ratio, and imperfect motion compensation. Despite these limitations, UTE MRI can now be considered as an alternative to multidetector computed tomography for the longitudinal follow-up of the morphological changes from lung diseases in neonates, children, and young adults, particularly as a complement to the unique functional capabilities of MRI.
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusions: The present study demonstrated that TLR4 and PPARα receptors would mediate the earliest control of bacterial replication as well as proinflammatory responses to PA infections, and in particular that PPARα receptors are needed to prevent an excessive inflammatory response, as in the control of the inflammasome complex NLP3 activation.
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
In this study, we investigated the role of CAR in the regulation of cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride transport in T84 human colonic epithelial cells and mouse intestinal tissues. Treatments of T84 cell monolayers with specific CAR agonists (CITCO and phenytoin at concentrations of 1 μM and 5 μM, respectively) for 24 h decreased transepithelial Cl− secretion in response to cAMP-dependent agonist. This inhibition was abolished by coincubation of CITCO with a CAR antagonist, CINPA1. We confirmed that an inhibitory effect of CAR agonists was no...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The purpose of this study was to systematically review the literature to investigate the effects of cyproheptadine as an appetite stimulator for underweight young people. Within clinical settings low weight-for-age remains a significant problem, especially in chronic disease such as cystic fibrosis, cancer, and eating disorders. Nutrition is known to be important for both physical and mental health outcomes.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Stakeholder engagement is a key component in developing educational initiatives aimed at improving adolescent and young adult (AYA) comprehensive care. This project describes a systematic approach to and evaluation of stakeholder engagement in the development of female AYA sexual and reproductive health (SRH) training for interprofessional cystic fibrosis (CF) healthcare providers.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
AbstractPlecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion initiating (1) the conversion of intracellular guanosine triphosphate to cyclic guanosine monophosphate, which increases the activity of the cystic fibrosis transmembrane conductance regulator to increase chloride and bicarbonate secretion into the intestinal lumen and (2) a decrease in activity of the sodium-hydrogen ion exchanger. The resulting ionic shifts cause an increase in lumenal fluid to facilitate digestion. Plecanatide has been approved by the FDA...
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
The National Institute for Occupational Safety and Health will oversee a study in 2019 to determine the feasibility of establishing the first national mesothelioma patient registry. The $100,000 feasibility study was part of the $1.2 million Congress allocated in 2019 to the Centers of Disease Control and Prevention for mesothelioma research. The bulk of the funding goes toward the National Mesothelioma Virtual Bank, which is a biospecimen registry first established in 2006. It is the only federally funded program designed exclusively for the research of mesothelioma, the rare and aggressive cancer caused by asbestos expos...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading to celiac disease. Prior epithelial stress and innate immune activation are essential for breaking oral tolerance to the gluten component gliadin. How gliadin subverts host intestinal mucosal defenses remains elusive. Here, we show that the α-gliadin-derived LGQQQPFPPQQPY peptide (P31–43) inhibits the function of cystic&nbs...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology, Membrane & Intracellular Transport, Molecular Biology of Disease Articles Source Type: research
Coeliac disease (CD) is an inflammatory autoimmune disease caused by ingestion of gluten proteins, mainly gliadin. Undigested gliadin proline-rich peptides trigger the innate and adaptive immune response, resulting in intestinal cell stress and damage. A new study by Villella et al (2019) addressing the unclear primary cause of intestinal cell stress reports that gliadin peptides inhibit the function of the chloride and bicarbonate channel CFTR, causing intestinal cell stress, which is sufficient to trigger CD symptoms. Notably, CFTR potentiators used to treat cystic fibrosis effectively rescue CFTR function and marke...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology, Membrane & Intracellular Transport, Molecular Biology of Disease News [amp ] Views Source Type: research
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