Microbubbles improve breast cancer radiation therapy

Injecting breast cancer with oxygen-filled microbubbles makes tumors three...Read more on AuntMinnie.comRelated Reading: ASTRO: Short radiation course safe for breast cancer LED device could predict skin damage from breast RT NEJM: RT boosts heart disease risk in breast cancer patients Robotic IMRT-APBI works well for breast cancer patients SABCS: Study links APBI to higher complication rates
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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(The North American Menopause Society (NAMS)) Thanks to advanced medical treatments, women diagnosed with breast cancer today will likely survive the disease. However, some treatment options put these women at greater risk for a number of other health problems. A new study out of Brazil shows that postmenopausal women with breast cancer are at greater risk for developing heart disease. Results are published online in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study aimed to reduce the risk of cardiovascular events through an optimization of the dose distribution on heart substructures in mediastinal HL patients with the adoption of different volumetric modulated arc therapy (VMAT) techniques, while maintaining the same risk of second cancer induction on lungs and breasts. MATERIALS AND METHODS: Thirty patients (15 males and 15 females, 15 bulky lesions) treated between 2012 and 2017 at our institution were selected. Disease extent was mediastinum plus neck (n = 10), mediastinum plus unilateral axilla (n = 10) and mediastinum alone (n = 10). Lungs, breasts,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
AbstractThe number of breast cancer (BC) survivors has been increasing lately, due to the improvement in early detection strategies and oncological treatments. However, BC survivors are 3 times as likely to develop heart failure (HF) within 5  years of cancer diagnosis, and 7/100 of them will develop HF in a median follow-up of 8.5 years. Furthermore, HF in BC survivors has a worse prognosis compared to other causes of HF. Anthracyclines and trastuzumab have been proven to improve survival. However, they are also considered as the main causative factors of HF in BC survivors. Old patients, those with a pre-existi...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Conclusions: We successfully designed and synthesized a novel radiotracer 68Ga-NOTAGA-GAP19 that targets Connexin43. Experiments in vitro demonstrated that the molecular probe 68Ga-NOTAGA-GAP19 can bind to Connexin43 in non-small cell lung cancer cell lines. Further research on this probe is necessary to verify its stability and imaging effect in vivo.Reference: [1] Schulz R, Gorge PM, Gorbe A, Ferdinandy P, Lampe PD, and Leybaert L. Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther. 2015;153:90-106. [2] Grek CL, Rhett JM, Bruce JS, Ghatnekar ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiochemistry & amp; Chelation Posters Source Type: research
WEDNESDAY, May 15, 2019 -- Health experts have long touted the benefits of a low-fat diet for preventing heart disease, but now a large study suggests it might do the same against breast cancer. Researchers found that eating low-fat foods reduced a...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The unexpected early termination of the WHI Trial of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) in mid-2002 triggered a rapid and dramatic decline in the use of MHT worldwide. This effect was primarily due to fears of increased risks for breast cancer and coronary heart disease purportedly seen in the cohort overall - aged 50 to 79 on randomization (mean 63 years and 12 years postmenopausal); a cohort comprised primarily of women much older than those who would typically be started on MHT in clinical practice.
Source: Maturitas - Category: Primary Care Authors: Tags: INV49 Source Type: research
Prevention is often called the best medicine — but research has shown that millions of Americans are not getting the preventive care they should to live long, healthy lives. Obstacles like inadequate access to care and financial barriers can keep people away from the doctor, but anxiety and feeling like care is unnecessary are also common deterrents. “There are a lot of things that every person could do to stay healthy, and this could help people to feel better, improve their quality of life and help them to live longer,” says Dr. Alex Krist, a professor of family medicine at Virginia Commonwealth Univer...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Longevity public health Source Type: news
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: This study showed that the 21-gene RS assay was not able to predict the benefit of PMRT for OS in women with T1-2 N1mic ER-positive HER2-negative breast cancer. However, further prospective larger sample-size trials are warranted to determine if a benefit exists. Introduction According to the latest Global Cancer Statistics 2018, breast cancer is still the most frequent cancer and the leading cause of cancer death among females worldwide (1). It is estimated that there will be about 2.1 million newly diagnosed female breast cancer cases and 627,000 cancer death in 2018 (1). The use of screening tests for ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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