Pharmacokinetics and Safety of Levetiracetam Extended-Release Tablets and Relative Bioavailability Compared with Immediate-Release Tablets in Healthy Chinese Subjects

ConclusionsAfter single and multiple doses, the absorption of levetiracetam ER was equal to IR, thetmax was significantly delayed, and theCmax andCss min were significantly decreased. Food did not affect the absorption of the levetiracetam ER tablet, but theCmax increased and thetmax was delayed. The levetiracetam ER tablet was well tolerated and found to be dose proportional from 500 to 2000  mg in healthy Chinese subjects.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research