Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

In conclusion, we show that selective disruption of Snord116 expression in the mediobasal hypothalamus models the hyperphagia of PWS.

Source: Journal of Clinical Investigation - January 30, 2018 Category: Biomedical Science Authors: Joseph Polex-Wolf, Brian Y.H. Lam, Rachel Larder, John Tadross, Debra Rimmington, Fàtima Bosch, Verónica Jiménez Cenzano, Eduard Ayuso, Marcella K.L. Ma, Kara Rainbow, Anthony P. Coll, Stephen O’Rahilly, Giles S.H. Yeo Source Type: research