Gleason grading after neoadjuvant hormonal therapy retains prognostic value for systemic progression following radical prostatectomy
Gleason grading after neoadjuvant hormonal therapy retains prognostic value for systemic progression following radical prostatectomy Prostate Cancer and Prostatic Diseases advance online publication, August 26 2014. doi:10.1038/pcan.2014.30 Authors: S B Stewart, J C Cheville, T J Sebo, I Frank, S A Boorjian, R H Thompson, M T Gettman, M K Tollefson, E C Umbriet, S P Psutka, E J Bergstralh, L Rangel &R J Karnes
iot S, Pasquier D Abstract Prostate cancer is a sensitive adenocarcinoma, in more than 80% of cases, to chemical castration, due to its hormone dependence. Locally advanced and/or high-risk cancer is defined based on clinical stage, initial prostate specific antigen serum concentration value or high Gleason score. Hormone therapy associated with radiation therapy is the standard of management and improves local control, reduces the risk of distant metastasis and improves specific and overall survival. Duration of hormone therapy, dose level of radiation therapy alone or associated with brachytherapy are controvers...
The aim of this study was to compare the cost-effectiveness and quality-adjusted life years (QALYs) of active monitoring (AM), radical prostatectomy (PR), and external-beam radiotherapy with neoadjuvant hormone therapy (RT) for localized prostate cancer. Microsimulations of radical prostatectomy, 3D-conformal radiotherapy, or active monitoring were performed using Medicare reimbursement schedules and clinical trial results for a target population of men aged 50–69 years with newly diagnosed localized prostate cancer (T1-T2, NX, M0) over a time horizon of 10 years. Quality-adjusted life years (QALYs) and costs were as...
CONCLUSIONS: Developmentally reprogrammed PCa cell models recapitulate features of clinically-advanced prostate tumors including downregulated Rb1/p53 and overexpression of Sox2 with Sox9. Sox9 is a marker of a transitional state that identifies PCa cells under the stress of therapeutic assault and facilitates progression to therapy resistance. Its expression may index the relative activity of the NF-κB pathway. PMID: 31919137 [PubMed - as supplied by publisher]
Conditions: Prostate Cancer; Chemotherapy Effect; Hormone Sensitive Prostate Cancer; Locally Advanced Prostate Carcinoma Interventions: Drug: Neoadjuvant chemotherapy combined with hormone therapy; Drug: Neoadjuvant hormone therapy; Procedure: Radical Prostatectomy (RP)+ extended lymph node dissection Sponsor: RenJi Hospital Not yet recruiting
ConclusionsProton beam radiotherapy for prostate cancer is feasible with a low rate of acute toxicity and promising late toxicity and effectivity.
CONCLUSIONS: Being overweight was associated with positive margins in patients with PCa undergoing RP after NHT. PMID: 31451070 [PubMed - as supplied by publisher]
Abstract OBJECTIVE: Docetaxel has been shown to be an effective chemotherapy agent when combined with androgen deprivation therapy for hormone sensitive metastatic prostate cancer (CaP). Since very high risk CaP has a high rate of occult metastatic disease and early recurrence, we hypothesize that patients with very high risk locally advanced CaP may benefit from docetaxel-based neoadjuvant chemohormonal therapy (NCHT). Thus, we conducted a retrospective study to identify the outcome of these patients treated with NCHT followed by radical prostatectomy (RP). PATIENTS AND METHODS: We retrospectively analyzed d...
Condition: Advanced Prostate Cancer Intervention: Drug: Zoladex and Casodex Sponsor: AstraZeneca Not yet recruiting