Hyoscine N-butylbromide for Preventing Propofol Injection Pain: A randomized, Placebo-controlled and Double-blind Study

In this study, the aim was to investigate the effect of the hyoscine N-butylbromide pretreatment on pain during propofol injection. Subjects and Methods: In this prospective, randomized, placebo-controlled and double-blind trial, 60 patients scheduled to undergo routine outpatient surgery under general anesthesia were allocated randomly to two groups: hyoscine N-butylbromide (n=30) and sodium chloride (n=30). Twenty (20) seconds after injection of 20 mg hyoscine N-butylbromide or 0.9 % sodium chloride, a 50-mg dose of propofol was injected within 2 –3 seconds. Ten seconds later, the pain intensity was assessed using a four-point scale; no pain: 0; mild: 1; moderate: 2; and severe: 3. Student's t test was used for parametric data and Pearson chisquare test was used for categorical data analysis. Results: The occurence of pain in the hyoscine N-butylbromide group (43.3%) was significantly lower than the control group (73.3%) (p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research