Is vitamin D supplement accompanied with narrow band UVB effective for treatment of vitiligo?

AbstractVitiligo is an acquired autoimmune depigmenting disorder that is the result of white macules formation in the skin and mucous membranes, caused by the loss of melanocytes. It has affected 0.4 to 2.0% of world ’s population. It has been hypothesized that Vitamin D is important for skin pigmentation, but the correlation between vitamin D and vitiligo treatment response needs to be evaluated. To evaluate vitamin D supplementation effect on the vitiligo area severity index in patients treated with narrow b and UVB (NB UVB). This clinical pilot randomized study was carried out on 48 vitiligo patients who admitted to the Department of Dermatology at Imam Khomeini Hospital. Patients were randomly divided into two groups: intervention group which received vitamin D supplementation with a dose of 50,000 u nits once every 2 weeks, for 8 weeks. The rest of the patients were put in control group and consumed placebo. Treatment with NB UVB irradiation with a starting dose of 0.3 j/CM2 was carried out twice a week for all patients. Our study included 21 males and 27 females. The mean age of patients wa s 28.08 years old. The disease’s duration ranged from 1 to 15 years, with the mean of 4.52 ± 4.2 years. Sex distribution and mean age were not significantly different in either groups. Vitamin D deficiency was seen in 32 (66.7%) of the patients. Vitiligo area severity index (VASI) score si gnificantly decreased from ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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In conclusion, our study provides a novel evidence of a significant positive association of sufficient 25(OH)D levels with the stability of the disease and a satisfactory repigmentation process in Caucasian adult vitiligo patients and strengthen the need to assess vitamin D status in vitiligo. The correlation between sufficient vitamin D levels and a satisfactory course of the disease opens the way for future randomized controlled trials assessing a possible beneficial role of vitamin D supplementation on vitiligo. PMID: 31414974 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Introduction: Vitiligo is a an acquired skin disorder which affects 1 to 2% of worldwide population characterized by achromic macules caused by progressive depigmentation due to loss of functional melanocytes in the epidermis. It is associated with elevated frequency of autoimmune diseases, suggesting an autoimmune etiology for vitiligo. Vitamin D is a lipophilic hormone which deficiency is also associated with autoimmune diseases. Recently, studies have tried to find a relationship between vitiligo and hypovitaminosis D, however this association remains unclear.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
This study aimed to perform a systematic review and meta-analysis on the association between vitamin D levels and AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
AbstractVitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this categ...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
CONCLUSIONS: It remains unknown whether vitamin D deficiency causes vitiligo. Larger controlled studies are required to prove whether low circulating vitamin D is a causative factor in vitiligo. PMID: 27605903 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Tags: Original article Source Type: research
Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Tags: Original article Source Type: research
Summary BackgroundVitamin D deficiency is associated with a number of autoimmune diseases. We completed a meta‐analysis of observational studies to establish whether there was a relationship between hypovitaminosis D and the autoimmune skin disease vitiligo. MethodsComprehensive search was applied in the MEDLINE and EMBASE databases from their inception to December 2015. Inclusion criteria were observational studies that assessed 25‐hydroxyvitamin D (25(OH)D) levels in adults with vitiligo. The main outcome was the mean difference in serum 25(OH)D level between patients with vitiligo and controls. ResultsOur search str...
Source: Photodermatology, Photoimmunology and Photomedicine - Category: Radiology Authors: Tags: Original Article Source Type: research
Abstract BackgroundVitamin D deficiency is associated with a number of autoimmune diseases. We completed a meta‐analysis of observational studies to establish whether there was a relationship between hypovitaminosis D and the autoimmune skin disease vitiligo. MethodsComprehensive search was applied in the MEDLINE and EMBASE databases from their inception to December 2015. Inclusion criteria were observational studies that assessed 25‐hydroxyvitamin D (25(OH)D) levels in adults with vitiligo. The main outcome was the mean difference in serum 25(OH)D level between patients with vitiligo and controls. ResultsOur search st...
Source: Photodermatology, Photoimmunology and Photomedicine - Category: Radiology Authors: Tags: Original Article Source Type: research
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