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Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds.

Conclusion: All women in breast or breast/ovarian cancer kindreds would benefit from being offered genetic testing irrespective of which causative genetic variants have been demonstrated in their relatives. PMID: 29371908 [PubMed]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Hered Cancer Clin Pract Source Type: research

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AbstractFemale gender, contraceptives, and menopausal hormone replacement treatments containing progesterone analogues associate with higher risk of meningiomas yet with lower risk of gliomas. Progesterone receptor (PR) expression and mifepristone treatment was highly discussed for meningiomas. However, much less is known in regard to progesterone actions in gliomas despite PR expression strongly correlates with their grade. Meningiomas and gliomas may grow faster during gestation; but paradoxically, parousity reduces lifetime risk of gliomas which can be explained with dichotomous cell growth-stimulating and inhibitory ac...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Researchers from Arizona State University and National Center for Nanoscience and Technology of the Chinese Academy of Sciences have developed a remarkable new way of killing tumors. They’ve developed robot-like nanoscale devices that cling to ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Nanomedicine Oncology Source Type: blogs
Researchers have been building simple molecular machines out of DNA for some years now. This approach to molecular machinery is well suited to applications that involve conditional activation based on the proteins present in the surrounding environment; a lot of the necessary functional parts already exist in DNA and just have to be assembled in the right way. The Oisin Biotechnologies cell-killing technology is a smaller example of the type than the approach here, in which sizable DNA containers are constructed. They carry a cargo that will disrupt local blood flow, and are triggered into opening by cancerous cell surface...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conditions:   HER2-Negative Metastatic Breast Cancer;   Recurrent Ovarian Cancer Interventions:   Drug: Durvalumab;   Drug: Eribulin Sponsors:   Amy Tiersten;   AstraZeneca;   Eisai Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The emerging healthcare model which is dominated by a small number of very large health systems will be characterized, in part, by in-house, sophisticated genomic and molecular lab testing by these systems. This is because these large health systems will have the capital to invest in their own"laboratories of excellence" within their system. Such is the case withIntermountain Healthcare which has its own in-house genomics laboratory called Intermountain Precision Genomics. Intermountain Health is one of the giant health systems with 37,000 employees, 22 hospitals, and more than 185 clinics. Here is the missi...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Business Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Pathology Informatics Reference Laboratories Test Kits and Source Type: blogs
CONCLUSION: These compounds appear to be promising to overcome breast cancer treatment failure. However, despite the interesting activities additional preclinical investigations are needed in further breast cancer cell/tumor models in vitro and in vivo. PMID: 29446727 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Sylvie Dolbeault Jean-Luc Kop With advances in breast cancer (BC) gene panel testing, risk counseling has become increasingly complex, potentially leading to unmet psychosocial needs. We assessed psychosocial needs and correlates in women initiating testing for high genetic BC risk in clinics in France and Germany, and compared these results with data from a literature review. Among the 442 counselees consecutively approached, 212 (83%) in France and 180 (97%) in Germany, mostly BC patients (81% and 92%, respectively), returned the ‘Psychosocial Assessment in Hereditary Cancer’ questionnaire. Based on the...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
A person can be considered medically high risk due to their or a family member's medical history. If you are considered medically as high risk, you get popped into the category of give them lots more medical attention and'lovely'tests.Now withthe progress of genomic testing, its no longer a big expensive, rare proposition. However, why do we only test the high risk people? These are the people who already know they are high risk. But that leaves a lot of people who don't know they are high risk and could be. This doesn't make sense. Some new research asks if it wouldn't it make more sense to test more people who aren'...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: breast cancer cancer prevention genetic testing ovarian cancer Source Type: blogs
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Source: Cancer Science - Category: Cancer & Oncology Authors: Tags: Review Article Source Type: research
ConclusionsDespite the results achieved at somatic levels by other researchers, these were not confirmed in our study at the germline level. Our results show the need to establish more predictive CpG sites in theBRCA promoter regions to optimize the MS-MLPA assay for the detection of germline hypermethylation as an effective pre-screening tool for whole-BRCA genetic analysis in HBOC, because we can not rule out the existence of germline promoter hypermethylation inBRCA.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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