Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds.

Conclusion: All women in breast or breast/ovarian cancer kindreds would benefit from being offered genetic testing irrespective of which causative genetic variants have been demonstrated in their relatives. PMID: 29371908 [PubMed]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Hered Cancer Clin Pract Source Type: research

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Condition:   Breast Cancer Interventions:   Drug: Letrozole;   Drug: Palbociclib;   Drug: Goserelin;   Diagnostic Test: Oncotype DX Breast Recurrence Score Sponsors:   NSABP Foundation Inc;   Genomic Health®, Inc.;   Pfizer Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Reuters Health) - Tests for BRCA1 and BRCA2 - gene mutations that raise the risk of breast and ovarian cancers - are not always done in U.S. women who are eligible to get them, a new study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
(Vanderbilt University Medical Center) Medically underserved women in the Southeast diagnosed with breast cancer or ovarian cancer missed out on genetic testing that could have helped them and their relatives make important decisions about their health, according to new research from Vanderbilt-Ingram Cancer Center.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study uses US community cohort data to assessBRCA1 andBRCA2 testing among medically underserved Medicare beneficiaries with breast cancer, ovarian cancer, or both.
Source: JAMA - Category: General Medicine Source Type: research
Publication date: 2018Source: Materials Today: Proceedings, Volume 5, Issue 8, Part 3Author(s): C. Lakshmi Anand, A.M. Hima Vyshnavi, Gilu Francis, S. Karthikeyan, P. Sanjay Kumar, P.K. Krishnan NambooriAbstractThe somatic mutations in TP53 may be considered as one of the major genomic reasons behind breast and ovarian cancers. These two types of cancers have been reported as the major terminal diseases among women, with breast cancer as the second and ovarian cancer as the fifth cause of death as per the WHO reports last year. However, the proneness of the disease varies from trait to trait and even from person to person....
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
AbstractPurpose of ReviewResearch over the past 25  years has revealed much about the architecture of predisposition to breast and ovarian cancer. There is now a general understanding that there are three broad categories of germline variation that may increase risk. First, there are the “high-penetrance” genes associated with a relative risk f or cancer of greater than 5 and demonstrating an autosomal dominant pattern of inheritance. At the other end of the spectrum are “low-penetrance” common variants. These variants are associated with minor increases in risk (commonly less than a relative r...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
August is National Breastfeeding Month. According to the Office on Women’s Health, breastfed babies have lower risks during their childhood of obesity, ear infections, asthma and other conditions. Breast milk is rich in nutrients and easier for babies to digest than formula. Breastfeeding can help a mother’s health and healing following childbirth and leads to a lower risk of type 2 diabetes, certain types of breast cancer and ovarian cancer. Unfortunately, African American mothers have the lowest rates of starting and continuing to breastfeed their infant. See the Guide to Breastfeeding from the Office of...
Source: BHIC - Category: Databases & Libraries Authors: Tags: Children and Teens Minority Health Concerns Source Type: blogs
Abstract BMI-1 (B-lymphoma Mo-MLV insertion region 1) is a key protein partner in polycomb repressive complex 1 (PRC1) that helps in maintaining the integrity of the complex. It is also a key player in ubiquitination of histone H2A which affects gene expression pattern involved in various cellular processes such as cell proliferation, growth, DNA repair, apoptosis and senescence. In many cancers, Overexpression of BMI1correlates with advanced stages of disease, aggressive clinicopathological behavior, poor prognosis resistance to radiation and chemotherapy. BMI1 is emerging as a key player in EMT, chemo-resistance...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
In this study, we found that miR-1284 was downregulated in breast cancer tissues and cell lines compared to normal control cells. Moreover, we showed that overexpression of miR-1284 significantly inhibited the proliferation, migration and invasion of breast cancer cells while promoting apoptosis. In terms of mechanism, we found that transcription factor ZIC2 was a target of miR-1284 in breast cancer cells. Through luciferase reporter assay, we demonstrated their direct interaction. Besides, qRT-PCR and western blot also indicated that miR-1284 overexpression inhibited the protein levels of ZIC2 in breast cancer cells. More...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
ConclusionsAn individualised approach is required for every patient. The adverse effects of endocrine therapy should be weighed against the potential benefits of extended therapy to better inform decision-making.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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