Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer.

Conclusion Enzalutamide demonstrated clinical activity and was well tolerated in patients with advanced AR-positive TNBC. Adverse events related to enzalutamide were consistent with its known safety profile. This study supports additional development of enzalutamide in advanced TNBC. PMID: 29373071 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research

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Publication date: December 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 189Author(s): Abhijit Mukherjee, Suvranil Ghosh, Rudraditya Sarkar, Satyajit Samanta, Sudipta Ghosh, Mahadeb Pal, Adinath Majee, Sukanta Kumar Sen, Bula SinghAbstractIn the progress of small molecule as drug candidates, 4-hydroxycoumarin based compounds bearing a crucial place as potent antibiotic agents with appreciable safety in drug invention. Being synthetically and easily obtainable, 4-hydroxycoumarin related compounds with planar structure have been promoted predominantly as DNA targeting agent. Nevertheless, here we ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Conclusion We identified two polymorphisms in CYP1B1 and ABCC2 associated with tumor pathological response following docetaxel or doxorubicin neoadjuvant monotherapy, respectively. Although further validation is required, these variants could be potential predictive genetic markers for treatment outcome in breast cancer patients.
Source: Pharmacogenetics and Genomics - Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research
Resumo Pensando nas comunidades virtuais como espa ço de interação e compartilhamento de experiências, principalmente entre indivíduos acometidos por doenças crônicas, objetivamos com este estudo, analisar o papel e natureza de suporte oferecido pelas comunidades virtuais às portadoras de câncer de mama. Estudo descritivo com abordagem qual itativa. Para coleta de dados foi utilizado o aplicativo Netvizz, extraindo dados dos cinco primeiros grupos abertos de câncer de mama do Facebook, no ano de 2016. Foram encontradas 2921 postagens, totalizando 1722 coment...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
Conditions:   Cancer (Colon Cancer, Breast Cancer, Lymphoma, Multiple Myeloma);   Elderly;   Antineoplastic Agents;   Cardiotoxicity Interventions:   Other: Intensive cardiovascular monitoring;   Other: No intervention Sponsors:   Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León;   IBSAL-Instituto de Investigación Biomédica de Salamanca, Fundación IECSCYL-IBSAL;   Instituto de Salud Carlos III Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
April Doyle, a single mom from Visalia, Cal., only lets herself look three months into her future. Since she was first diagnosed with breast cancer in 2014, she’s tried a new treatment every three months to keep the cancer from spreading from her breast tissue to other parts of her body. But it returned: this time in her bone. She is almost out of options for her hard-to-treat cancer, but she finds comfort in online support groups where other women with metastatic breast cancer share their experiences. “Eventually we know we will exhaust all of our options until they keep coming up with more treatments,” ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news
Afinitor is billed as the biggest advance for sufferers in years after a study found it could halt the growth of tumours or even shrink them for nearly eight months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
SUMMARY Cancer is characterized by the disordered growth of cells that have high capacity of invasion to the tissues and organs. One of the types of tumour that has national incidence and high mortality is breast cancer. Studies show that in addition to hereditary factors, lifestyle and environmental factors, there are factors related to emotional distress (mourning), which interfere with the development of breast cancer. Thus, it is necessary to investigate if the experience of mourning can trigger the appearance of the tumour. For this, an integrative review was performed to verify the existence of the relationship betwe...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
CONCLUSION: The translation of BCTOS into Portuguese will help us to evaluate the quality of life in BCT patients evaluating treatment-related sequelae and may be useful for oncoplastic surgery evaluation.RESUMO INTRODU ÇÃO: O tratamento conservador da mama (TCM), desde que associado à radioterapia, é seguro. As indicações inicialmente utilizadas para o TCM se elevaram, sendo importante modalidade de tratamento. Novas modalidades, como a oncoplastia associada ao TCM, tornam-se cada vez mais presentes no cotid iano. Pacientes submetidas ao TCM apresentam alguns parâmetros asso...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
ConclusionPanniculitis of the breast is a rare condition that needs to be included in the differential diagnosis of subcutaneous breast masses. In all cases, but specifically in females with history of breast cancer, panniculitis still should be thought of as a possibility, and imaging as well as other diagnostic techniques can aid in making the correct diagnosis.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Here's what you need to know about breast cancer disparities, and why do they still exist?
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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