Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility.
This study aimed to examine the effect of mesalazine on fertility. In this retrospective analysis of 1,225 male subfertile patients, we reviewed the cases of inflammatory bowel disease (IBD) in the medical records and evaluated the prevalence of the disease in our reproduction center. Specifically, we examined IBD patients who ceased mesalazine during male infertility treatment, and compared the seminogram of these patients before and after discontinuation of mesalazine. We also analyzed pregnancy outcome after discontinuation. The prevalence rate of Crohn's disease and ulcerative colitis in our male infertile patients was 163 per 100,000 men and 490 per 100,000 men, respectively. Seven patients had taken mesalazine and six of them subsequently stopped the medication. The mean values of sperm concentration, sperm motility, percentage of normal formed sperm, semen volume, and total motile sperm count taken before discontinuation increased after discontinuation of mesalazine. Among these parameters, the sperm motility and total motile sperm count were significantly improved (p
Infants born at 23 to 27 weeks of pregnancy are most vulnerable.
Publication date: Available online 19 February 2020Source: The LancetAuthor(s): Håvard Ove Skjerven, Eva Maria Rehbinder, Riyas Vettukattil, Marissa LeBlanc, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Linn Landrø, Benjamin J Marsland, Knut Rudi, Kathrine Dønvold Sjøborg, Cilla Söderhäll, Anne Cathrine Staff, Kai-Håkon Carlsen, Anna Asarnoj, Karen Eline Stensby Bains, Oda C Lødrup Carlsen, Kim M Advocaat Endre, Peder Annæus Granlund, Johanne Uthus HermansenSummaryBackgroundSkin emollients applied during early infancy could prevent atopic dermatitis, and early comple...
Feuerstein et al1 conclude that chromoendoscopy is superior to standard-definition white-light endoscopy (SDWLE) but not superior to high-definition white-light endoscopy (HDWLE) in patients with inflammatory bowel disease. They base this conclusion on an analysis of 2 subgroups (chromoendoscopy vs SDWLE and ch romoendoscopy vs HDWLE) within their meta-analysis of randomized trials of chromoendoscopy versus white-light endoscopy. However, their interpretation of this subgroup analysis is incorrect.
In this long ‐term follow‐up of women with GDM, we found that 2‐hour glucose during OGTT at pregnancy predicted β‐cell function (as measured by ODI) 22 years post‐partum. Results of 2‐hour glucose during OGTT at pregnancy is a more useful indicator of long‐term metabolic risk. Most of the cases wh ich later converted to type 2 diabetes occurred within the first 15 years postpartum. AbstractAims/IntroductionWomen with gestational diabetes mellitus are at increased risk for type 2 diabetes. We characterized the association between maternal glycemia during pregnancy with long‐term outcomes.Methods a...
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
ConclusionsThere is no clear evidence that the use of drugs during pregnancy and during the first year of life is associated with HSPM. Further well-designed prospective studies are needed.Clinical relevanceDetermining the etiological factors related to the development of HSPM would help to establish preventive protocols in patients at potential risk. As HSPM is predictive of molar incisor hypomineralisation (MIH), the application of preventive protocols would avoid complications in both the primary and permanent dentition.
In conclusion, the integrated strategy provides novel insights into network pharmacology and metabolomics as effective tools to illuminate the mechanism of action of TCM. PMID: 32070601 [PubMed - in process]
In a first of its kind case, a baby was born to a mother left infertile from cancer through IVM and egg freezing.
[UNFPA in WCA] Bamako, February 20, 2020, On Thursday, February 20, the Regional Office of the United Nations Population Fund (UNFPA) for West and Central Africa (WCARO) is organizing a session on "Demography, Peace and Security" as part of the 20th edition of the Bamako Forum "Africa on the horizon 2040: between memories and futures" which is held from February 20 to 22, 2020 in Bamako, Mali under the High Patronage of the President of the Republic of Mali, His Excellency Ibrahim Boubacar Keita.
CONCLUSIONS: We found limited evidence of an association between prenatal traffic and ambient air pollution exposure and infant body composition. Suggestive associations between prenatal ozone exposure and early postnatal changes in body composition merit further investigation. PMID: 32069764 [PubMed - in process]