Study: Hospital Patients Still More Likely To Die On Weekends

By Michael Nedelman, CNN (CNN) — Doctors call it the “weekend effect.” Patients in the hospital are more likely to die off-hours — whether it’s due to a brain bleed, a heart attack or a clot in the lungs. New research on cardiac arrest in the hospital now asks: Has the “weekend effect” changed in recent years, as treatment has gotten better? “We know that survival trends have improved in past decade or so,” said Dr. Uchenna Ofoma, assistant professor of medicine at Temple University and a critical care physician at Geisinger Health System in Danville, Pennsylvania. “The question now becomes … what happens to the disparities? Has it remained the same? Is it narrowing?” Ten years after a 2008 study showed lower survival rates during nights and weekends for in-hospital cardiac arrest, Ofoma published a new study this week in the Journal of the American College of Cardiology. The new study builds on that previous research, finding that treatment has indeed gotten better, but we haven’t closed the nights-and-weekends gap. Between 2000 and 2014, weekday survival jumped from 16% to 25.2%, while weekend and weeknight survival rose from 11.9% to 21.9%, according to the new study’s risk-adjusted numbers. There was no significant change in the gap between weekday and off-hours survival, the study said. About half of patients in the study — more than 150,000 patients from 470 US hospitals — e...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News cardiac arrest Source Type: news

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HEART attack symptoms include chest pain, headaches and dizziness. But you could also be at risk of a deadly myocardial infarction if you have this one sign while lying asleep in bed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPoor homing of cells after transplantation is an unresolved common issue in cardiac cell therapies. To enhance stem cell homing, the ligand CXC motif chemokine 12 (CXCL12) and its specific receptor CXC receptor type 4 (CXCR4) have been employed as a system in this study to show that induced expression of the endogenous CXCR4 gene in mouse-induced pluripotent stem cells (iPSCs) improved the cell migration. Loci-specific epigenome editing in the form of CpG demethylation at CXCR4 promoter region of the mouse iPSCs was accomplished with CXCR4b-TAL-Tet1c, chimeric fusion proteins of the catalytic domain of ten-eleven t...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Conclusions Toxicity was encountered with the combination therapy of BGJ398 and imatinib. Due to withdrawal of sponsor support the study closed before the RP2D or dosing schedule of the combination therapy was identified. In heavily pre-treated patients, stable disease ≥ 32 weeks was observed in 3 of 12 evaluable patients. Trial Registration:NCT02257541.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractAcute coronary syndrome (ACS) encompasses a range of thrombotic coronary artery diseases. Protein Z (PZ)/PZ-dependent protease inhibitor complex is a natural anticoagulant system with a presumptive role for PZ deficiency in the pathogenesis of ACS. We aimed to evaluate plasma PZ level and role as a risk biomarker in Egyptian patients with ACS. Hundred patients with stable ACS and 60 matched controls were enrolled. ACS patients were divided into 3 clinical subgroups (ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina), and 2 age subgroups (group A  ...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
In this study, we aim to investigate the effect of StemBell therapy on atherosclerotic plaques in an atherosclerotic mouse model after MI. Methods. MI was induced in atherosclerotic Apolipoprotein E–deficient mice that were fed a high-fat Western diet. Six days post-MI, the mice received either 5 × 105/100 µL StemBells or vehicle intravenously. The effects of StemBell treatment on the size and stability of aortic root atherosclerotic plaques and the infarcted heart were determined 28 days post-MI via (immuno)histological analyses. Moreover, monocyte subtypes and lipids in the blood were studied. ...
Source: Cytotherapy - Category: Cytology Source Type: research
Publication date: Available online 11 August 2018Source: Biosensors and BioelectronicsAuthor(s): Tong Zhang, Ning Ma, Asghar Ali, Qin Wei, Dan Wu, Xiang RenAbstractThe accurate and rapid detection of cardiac troponin I (cTnI) at an early stage can prevent people from getting acute myocardial infarction to a great extent. Here, an ultrasensitive sandwich-type electrochemical immunosensor for the quantitative detection of cTnI is designed based on a novel signal amplification strategy. Gold nanoparticles (Au NPs) doped covalent organic frameworks (COFs) and electron mediator toluidine blue (TB-Au-COFs) behave as labels for a...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
ConclusionThus, present study provides evidences for efficacy of NRF against isoproterenol induced myocardial infarction in rats.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 11 August 2018Source: Cor et VasaAuthor(s): Ondřej Černý, Tomáš Roubíček, Jindřich Kupec, Rostislav PolášekAbstractDespite tremendous achievements in myocardial infarction therapy, thromboembolic complications remain very serious and its prognosis often fatal. Postinfarction cardioembolic stroke is the most frequent and has the highest mortality of all ischemic stroke subtypes. In this case report we describe cardioembolic stroke from postinfarction apical left ventricular aneurysm as a first symptom of myocardial infarction. In brief literatu...
Source: Cor et Vasa - Category: Cardiology Source Type: research
Authors: Kim Y, Ahn Y, Kim I, Lee DH, Kim MC, Sim DS, Hong YJ, Kim JH, Jeong MH Abstract BACKGROUND AND OBJECTIVES: Feasibility of coronary angiography (CAG) and percutaneous coronary intervention (PCI) via left snuffbox approach is still concerned. We aimed to investigate efficacy and safety of the left snuffbox approach for CAG and PCI. METHODS: Left snuffbox approach was tried in 150 patients who planned to perform CAG or PCI for suspected myocardial ischemia between 1 November 2017 and 31 March 2018. RESULTS: Success rate of radial artery (RA) cannulation via snuffbox approach was 88.0% (n=132). Among 1...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: In our cohort, DSE had a low sensitivity but high NPV in predicting perioperative MACE post OLT. A similar trend was noted for DSE in predicting 1-year MACE post OLT. We reiterate the need of a better screening and risk stratification tool for OLT. PMID: 30088354 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
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