A three-year prospective study of the presentation and clinical outcomes of major bleeding episodes associated with oral anticoagulant use in the UK (ORANGE study).

A three-year prospective study of the presentation and clinical outcomes of major bleeding episodes associated with oral anticoagulant use in the UK (ORANGE study). Haematologica. 2018 Jan 25;: Authors: Green L, Tan J, Morris JK, Alikhan R, Curry N, Everington T, Mclean R, Saja K, Stanworth S, Tait C, MacCallum P Abstract The outcomes of patients developing major bleeding on oral anticoagulants remain largely unquantified. Objectives are to: 1) describe the burden of major haemorrhage associated with all available oral anticoagulants in terms of: proportion of bleeds which are intracranial-haemorrhages, in-hospital mortality and duration of hospitalisation following major bleeding; 2) identify risk factors for mortality; 3) compare characteristics of major haemorrhage between warfarin and direct-oral anticoagulants for the subgroup of atrial fibrillation and venous-thromboembolism patients. A multi-centre, three-year prospective cohort study of patients aged ≥18 on oral anticoagulants who developed major haemorrhage leading to hospitalisation. Follow-up was for 30 days or until discharge or death, whichever occurred first. In total 2,192 patients (47% female, 81% warfarin, median age 80 years) were reported between October 2013 and August 2016 from 32 UK hospitals. Bleed sites were: intracranial-haemorrhage (44%); gastrointestinal (33%); and other (24%). The in-hospital mortality was 21% (95%CI: 19%-23%) overall, and 33% (95%CI: 30...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research