New approach to identify 'drivers' of cancer developed

A new integrated approach to pinpoint the genetic “drivers” of cancer has been developed by scientists, uncovering eight genes that could be viable for targeted breast cancer therapy. While the study focused on identifying genetic drivers for breast cancer, the approach could easily be applied to other tumors types as well, authors note.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Mol Med Rep. 2019 Mar 14;: Authors: Cai F, Cai L, Zhou Z, Pan X, Wang M, Chen S, Luis MAF, Cen C, Biskup E Abstract Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to investigate the association of Tif1&gam...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: Available online 21 March 2019Source: European Polymer JournalAuthor(s): Aliyeh Ghamkhari, Farideh Mahmoodzadeh, Marjan Ghorbani, Hamed HamishehkarAbstractGold nanoparticles have been used for centuries in medicine for clinical procedures. In this context, gold nanorods are considered as very promising in cancer therapy. For this purpose, gold nanorods (GNRs) coated by stimuli-responsive thiol-end capped ABC triblock copolymer [poly (metacrylic acid)-block-poly (N-isopropylacrylamide)-block-poly (N,N-dimethylaminoethyl methacrylate)-SH; P(MAAc-b-NiPAAM-b-DMAEMA)-SH] for intracellular delivery of doxorubic...
Source: European Polymer Journal - Category: Chemistry Source Type: research
ConclusionsHematologic adverse events were common in palbociclib ‐treated cancer patients. Since palbociclib produced a higher PFS rate with a low serious complication rate, it can be a promising novel target therapy drug for treating ER‐positive and HER2‐negative breast cancer.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 19 March 2019Source: European Journal of Integrative MedicineAuthor(s): Shiao Li Oei, Anja Thronicke, Matthias Kröz, Cornelia Herbstreit, Friedemann SchadAbstractIntroductionViscum album L. extracts (VA) are frequently used in integrative oncology to enhance health-related quality of life. As a central aspect of well-being is associated with feeling warm or cold the internal coherence scale (ICS) questionnaire including the thermo coherence measurement was utilized.MethodsA prospective observational longitudinal cohort study was conducted, using data from the Network Oncology clinica...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial resolution of immune cells with laser capture microdissection gene expression profiles, we defined distinct TIME stratification in TNBC, with implications for current therapies including immune checkpoint blockade. TNBCs with an immunoreactive microenvironment exhibited tumoral infiltration of granzyme B+CD8+ T cells (GzmB+CD8+ T cells), a type 1 IFN signature, and elevated expression of multiple immune inhibitory molecules including indoleamine 2,3-di...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionThe combined regimen of the proteasome inhibitor delanzomib with Dox chemotherapy may become an effective strategy for breast cancer therapy.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Authors: Zhao L, Zhou S, Gustafsson JÅ Abstract Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human physiology and pathology, serving as sensors of stimuli, master regulators of downstream molecular events and hubs governing complex gene regulatory networks. The importance of various members of the NR superfamily in cancer has led to substantial efforts to target them therapeutically. Notably, drugs that block the action of estrogen receptor alpha (ERα) in patients with ERα+ breast cancer or the androgen receptor (AR) in prostate cancer patients have provid...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionsThe results show that the psychological intervention group is efficient to improve emotional state and quality of life of women with breast cancer.ResumenAntecedentes/ObjetivoEl cáncer de mama provoca niveles altos de ansiedad y depresión, empeorando la calidad de vida (CV) de las pacientes. En numerosos estudios se ha visto que la terapia grupal reduce la depresión y ansiedad además de mejorar la CV. El objetivo de este estudio es analizar la efectividad de la intervención de la terapia grupal en el estado emocional y la CV de mujeres con cáncer de mama localizado al fi...
Source: International Journal of Clinical and Health Psychology - Category: Psychiatry & Psychology Source Type: research
Volume 47, Issue 1, December 2019, Page 705-714 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
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