Assistive Technology for Persons with Alzheimer's Disease and Related Dementias and Their Caregivers (R41/R42 - Clinical Trials Optional)

Funding Opportunity PAR-18-587 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) research and development of assistive technology for individuals with Alzheimer's disease and related dementias (ADRD) and their caregivers/care partners, to enhance their health and well-being, reduce illness and disability, and improve quality of life. Particularly of interest are technologies for providing psychosocial support (enhancing mood, mitigating the effects of loneliness, and enhancing social connection and communication), reducing stress (e.g., through the provision of biofeedback or other forms of behavioral therapy) and assisting with care management and activities of daily living. To achieve these ends, this FOA encourages a multi-disciplinary approach to foster collaborations between geriatricians (particularly those with knowledge of cognitive impairment and dementia), psychologists, neurologists, computer scientists, and mechanical, electrical and software engineering professionals. Applications should demonstrate the potential for broad population impact, including that the proposed assistive technology is: 1. Innovative 2. Efficacious and effective 3. Scalable 4. Low-cost
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

Related Links:

Authors: Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar S Abstract As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities, resulting in a lower quality of life and unusually high costs of health and social care. One of the most difficult problems associated with the pathology of the brain after ischemia is progressive dementia observed in people who survived the stroke. More recently, brain ischemia has been shown to el...
Source: Folia Neuropathologica - Category: Neurology Tags: Folia Neuropathol Source Type: research
Psychosis and/or aggression are common problems in dementia, and when severe or persistent, cause considerable patient distress and disability, caregiver stress, and early institutionalization. In 2005, the Food and Drug Administration (FDA) determined that atypical antipsychotics were associated with a significantly greater mortality risk compared to placebo, which prompted the addition of an FDA black-box warning. The American College of Neuropsychopharmacology (ACNP) White Paper, 2008, reviewed this issue and made clinical and research recommendations regarding the use of antipsychotics in dementia patients with psychos...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Current state of knowledge makes the usage of cholesterol markers of cognitive decline in clinical practice impossible. PMID: 31530269 [PubMed - as supplied by publisher]
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
“Get out! Get out!” My wife, Joan, having just woken up, was screaming, and hitting out wildly at the stranger in her bed. She was in a panic, her body shaking with fright. “Get away from here. Get out!” The man she perceived as a stranger was me, her husband of more than forty years. Joan was eight years into the destructive course of atypical early-onset Alzheimer’s disease, a horrific disorder that ravaged her, leaving her blind and with serious dementia. At that moment, she was experiencing something called Capgras Syndrome, in which patients become deluded that those close to them and the...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Books health ideas Source Type: news
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Six of my most important tips for dealing with an Alzheimer's patient during a hurricane.By Bob DeMarcoAlzheimer's Reading RoomI took care of my mom, Dotty, for eight and a half years, 3,112 days.My mom lived with Alzheimer's disease.We survived 2 hurricanes together including monsterhurricane Wilma. A category 3 hurricane when it reached our home in Delray Beach, Florida.Here are 6 of my most important tips for dealing with an Alzheimer's patient during a hurricane.12 Ways to Control CareGiver Stress and SadnessListen Now or Continue ReadingSubscribe to the Alzheimer's Reading RoomEmail:#1 It's Not Their FaultMy mom acted...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers care Alzheimers Disease alzheimers help alzheimers hurricane care of dementia patients florida disaster hurricane alzheimers natural disaster Source Type: blogs
Authors: Amieva H, Meillon C, Proust-Lima C, Dartigues JF Abstract BACKGROUND: Dementia, stroke, depression, and disability are frequent in late life and are major causes of quality of life disruption and family burden. Even though each of these disorders relies on specific pathogenic processes, a common clinical manifestation is psychomotor slowing. OBJECTIVE: We assessed the relevance of a simple marker of low psychomotor speed in predicting several brain outcomes: dementia, Alzheimer's disease (AD), Parkinson's disease (PD), stroke, depressive symptoms, and disability in activities of daily living (ADL) and ...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
AbstractAlthough cognitive and functional impairment are the hallmark features of Alzheimer ’s disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of disability and profoundly impact the quality of life of both patients and their caregivers. This narrative review of current evidence provides practical guidance in diagnosing and managing depression in pa tients with AD using pharmacological and nonpharmacological interventions. After apathy, depression is the second most common neuropsychiatric symptom in AD. Diagnosing late-life depression (LLD), particularly in those affected by AD...
Source: Neurology and Therapy - Category: Neurology Source Type: research
In this study we describe a heterogeneous network-based data set for Alzheimer's disease (HENA). Additionally, we demonstrate the application of state-of-the-art graph convolutional networks, i.e. deep learning methods for the analysis of such large heterogeneous biological data sets. We expect HENA to allow scientists to explore and analyze their own results in the broader context of Alzheimer's disease research. PMID: 31413325 [PubMed - in process]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Sci Data Source Type: research
More News: Alzheimer's | Brain | Clinical Trials | Computers | Contracts | Dementia | Disability | Funding | Geriatrics | Grants | Neurology | Psychology | Research | Small Businesses