One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media.

One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media.
Comb Chem High Throughput Screen. 2018 Jan 23;:
Authors: Taherkhorsand H, Nikpassand M
Abstract
A clean and environmentally benign route to synthesize a novel series of 4-thiazolidinone derivatives using the reaction between various synthetized pyrazolcarbaldehydes, thioglycolic acid and different anilines as a three component reaction, instead of two step reaction reported previously, in the presence of 1,4-disulfo-1,4-diazoniabicyclo[2.2.2]octane chloride (DSDABCOC) as a novel ionic liquid media, is reported. The present methodology offers several advantages such as mild conditions, simple procedure, excellent yields and reduced environmental consequences. The ionic liquid was recovered and reused. The structures of the synthesized pyrazolo-4-thiazolidinone compounds were confirmed by 1H, 13C NMR and FTIR spectral data and elemental analyses.
PMID: 29366410 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - January 23, 2018 Category: Chemistry Authors: Taherkhorsand H, Nikpassand M Tags: Comb Chem High Throughput Screen Source Type: research