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Survivin is a negative prognostic factor in malignant pleural effusion.

Survivin is a negative prognostic factor in malignant pleural effusion. Eur J Clin Invest. 2018 Jan 23;: Authors: Arellano-Orden E, Romero-Romero B, Sánchez-López V, Martín-Juan J, Rodríguez-Panadero F, Otero-Candelera R Abstract SURVIVIN: is a well-known member of the inhibitor of apoptosis family, and has been related with increased tumour aggressivity, both in tissue and in pleural fluid. OBJECTIVES: In patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. METHODS: We investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer, and 27 mesothelioma. Serial samples of pleural fluid were obtained before thoracoscopy (baseline) and 24 h thereafter. RESULTS: Survivin levels were successfully quantified in all pleural fluid samples, and they were significantly higher in samples obtained after thoracoscopic talc poudrage compared with baseline (p
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Eur J Clin Invest Source Type: research

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The second trial involving Johnson &Johnson’s iconic baby powder and its possible link to mesothelioma began this week in a Middlesex County, New Jersey, superior court. A jury in California two months ago — in a highly anticipated first trial — found the pharmaceutical giant was not responsible for a plaintiff’s mesothelioma, the rare asbestos-related cancer. Superior Court Judge Ana Viscomi opened the latest trial Monday in New Brunswick, New Jersey, just a few blocks from the world headquarters of Johnson &Johnson. The trial is estimated to last two months. Plaintiff Stephen Lanzo III, 46...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Abstract Survivinis a well‐known member of the inhibitor of apoptosis family, and has been related with increased tumour aggressivity, both in tissue and in pleural fluid. ObjectivesIn patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. MethodsWe investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer, and 27 mesothelioma. Serial sample...
Source: European Journal of Clinical Investigation - Category: General Medicine Authors: Tags: Original Paper Source Type: research
Conclusion: PTX3 could be a promising biomarker to differentiate PPE from other causes of pleural effusions. In PPE, an increased level of pleural fluid PTX3 level without a significant increase in serum PTX3 level may reflect a more intense local inflammation than those occur in MPE or TPE.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
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Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: CAR T cell therapy checkpoint blockade chimeric antigen receptor T cell therapy Dr. Andy Haas Dr. Prasad Adusumilli Dr. Scott Gottlieb FDA Commissioner gene therapy cancer gene therapy for mesothelioma immunotherapy clinical trial mali Source Type: news
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Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: acupuncture cancer Alternative medicine alternative mesothelioma treatment alternative therapy survival alternative vs conventional medicine breast cancer colon cancer Conventional cancer treatments Dr. David Gorski Dr. Skyler Johnson Source Type: news
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Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: African medicinal plants African whitewood apoptosis mesothelioma BMC Complementary and Alternative Medicine breast cancer Cameroon cancer chemotherapy colon cancer cytotoxicity against mesothelioma cells doxorubicin Dr. Victor Kuete Source Type: news
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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
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Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: General Information Source Type: news
Conclusion LAT can be provided by a DGH as a safe and effective procedure with minimal length of stay and a high diagnostic yield. Normal macroscopic pleural appearance is a sensitive marker of absence of malignancy.References 1. BTS Pleural Disease Guideline 2010: BTS Guidelines for the Management of Pleural Disease. Thorax 2003 May; 58(Suppl 2): 1–59.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 1.4 Interventional Pulmonology Source Type: research
Conclusion: pleural ultrasonic elastography is a valuable and effective technique in differentiating MPE from benign pleural effusion and may become an important adjunct in diagnostic methods.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 11.2 Pleural and Mediastinal Malignancies Source Type: research
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