Survivin is a negative prognostic factor in malignant pleural effusion.

Survivin is a negative prognostic factor in malignant pleural effusion. Eur J Clin Invest. 2018 Jan 23;: Authors: Arellano-Orden E, Romero-Romero B, Sánchez-López V, Martín-Juan J, Rodríguez-Panadero F, Otero-Candelera R Abstract SURVIVIN: is a well-known member of the inhibitor of apoptosis family, and has been related with increased tumour aggressivity, both in tissue and in pleural fluid. OBJECTIVES: In patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. METHODS: We investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer, and 27 mesothelioma. Serial samples of pleural fluid were obtained before thoracoscopy (baseline) and 24 h thereafter. RESULTS: Survivin levels were successfully quantified in all pleural fluid samples, and they were significantly higher in samples obtained after thoracoscopic talc poudrage compared with baseline (p
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Eur J Clin Invest Source Type: research

Related Links:

Abstract Proteomics-based analyses are powerful means of identifying potentially useful proteins in the initial stage of drug development. Technological developments in the field of proteomics, and increases in the sensitivity of MS analyses, now facilitate identification and examination of increasingly small amounts of proteins that are differentially expressed in diseased versus normal tissues and can be candidate biomarkers or therapeutic targets. However, the current approach is for candidate proteins to be prioritized by research interest and then validated one by one; this is very inefficient. To address thi...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Immunotoxins (antibody conjugates) target cancer cells while allowing normal cells to survive.  As a result, patients receiving immunotoxins are less likely to experience the deleterious side-effects associated with non-specific therapies such as chemotherapy.  In order to make an effective immunotoxin, three components are generally required: a targeting domain, a toxic payload molecule su ch as Pseudomonas exotoxin A (PE), and a furin cleavage site (FCS).   The purpose of the FCS is to allow the toxin domain to be processed by the target cell so that it can exert its toxic effect.Researchers at the Nationa...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
The National Cancer Institute,Laboratory of Molecular Biologyseeks parties interested in collaborative research to further co-develop monoclonal antibodies for the treatment of mesothelin-expressing cancers. The antibody was able to inhibit tumor growth in mouse xenograft models, and corresponding immunotoxins were able to inhibit tumor cell growth in vitroMesothelin is a cell surface protein that is highly expressed in aggressive cancers such as malignant mesothelioma, ovarian cancer, pancreatic cancer, lung cancer, breast cancer, cholangiocarcinoma, bile duct carcinoma and gastric cancer. This selective expression makes ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
CONCLUSIONS: The main cause of MPE in our setting was lung cancer, followed by breast cancer, unknown primary and mesothelioma. Chemical pleurodesis was a viable palliative measure for MPE in this population. PMID: 29629675 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
The second trial involving Johnson &Johnson’s iconic baby powder and its possible link to mesothelioma began this week in a Middlesex County, New Jersey, superior court. A jury in California two months ago — in a highly anticipated first trial — found the pharmaceutical giant was not responsible for a plaintiff’s mesothelioma, the rare asbestos-related cancer. Superior Court Judge Ana Viscomi opened the latest trial Monday in New Brunswick, New Jersey, just a few blocks from the world headquarters of Johnson &Johnson. The trial is estimated to last two months. Plaintiff Stephen Lanzo III, 46...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Abstract Survivinis a well‐known member of the inhibitor of apoptosis family, and has been related with increased tumour aggressivity, both in tissue and in pleural fluid. ObjectivesIn patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. MethodsWe investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer, and 27 mesothelioma. Serial sample...
Source: European Journal of Clinical Investigation - Category: General Medicine Authors: Tags: Original Paper Source Type: research
Conclusion: PTX3 could be a promising biomarker to differentiate PPE from other causes of pleural effusions. In PPE, an increased level of pleural fluid PTX3 level without a significant increase in serum PTX3 level may reflect a more intense local inflammation than those occur in MPE or TPE.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Treatment options for malignant mesothelioma may soon include customized gene therapy, according to thoracic surgeon and scientist Dr. Prasad Adusumilli at Memorial Sloan Kettering Cancer Center in New York. Gene therapy involves a laboratory reprogramming of a patient’s own T cells, which are a type of white blood cell, to recognize and destroy the cancer. The U.S. Food and Drug Administration (FDA) recently approved the first gene therapy specifically for pediatric leukemia, signaling the start of a new approach to cancer treatment in this country. The newly approved treatment is also known as chimeric antigen rece...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: CAR T cell therapy checkpoint blockade chimeric antigen receptor T cell therapy Dr. Andy Haas Dr. Prasad Adusumilli Dr. Scott Gottlieb FDA Commissioner gene therapy cancer gene therapy for mesothelioma immunotherapy clinical trial mali Source Type: news
Cancer patients who opt for alternative therapy instead of conventional medicine significantly decrease their chances of survival, according to researchers at Yale School of Medicine. Although the popularity of alternative medicine continues to grow, a recent study published in the Journal of the National Cancer Institute found survival rates significantly reduced for those who use it as first-line therapy. Conventional cancer treatments — chemotherapy, surgery and radiation — still produce a much better chance of survival. Mesothelioma was not included in the study, but the findings are relevant to this rare ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: acupuncture cancer Alternative medicine alternative mesothelioma treatment alternative therapy survival alternative vs conventional medicine breast cancer colon cancer Conventional cancer treatments Dr. David Gorski Dr. Skyler Johnson Source Type: news
This study provides evidences of the cytotoxicity of the tested plant extract and highlights the good activity of Elephantopus mollis and Kalanchoe crenata,” Kuete wrote. “They deserve more exploration to develop novel cytotoxic drugs.” The post Methanol from African Plants Kills Mesothelioma Cells appeared first on Mesothelioma Center - Vital Services for Cancer Patients &Families.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: African medicinal plants African whitewood apoptosis mesothelioma BMC Complementary and Alternative Medicine breast cancer Cameroon cancer chemotherapy colon cancer cytotoxicity against mesothelioma cells doxorubicin Dr. Victor Kuete Source Type: news
More News: Asbestosis | Breast Cancer | Cancer | Cancer & Oncology | Lung Cancer | Mesothelioma