Breast Cancer Stage at Diagnosis in a New Jersey Cancer Education and Early Detection Site.

This study will provide a first snapshot of the effectiveness of the New Jersey program, by comparing stage at diagnosis for enrollees as compared with nonenrollees who received definitive treatment for breast cancer at the same academic medical center. MATERIALS AND METHODS: A retrospective analysis of 5 years of breast cancer data abstracted from the Cancer Registry of a large urban hospital in the Northeast United States. Bivariate analysis and logistic regression were utilized. RESULTS: One thousand forty women were screened for and diagnosed with breast cancer at this site; they were more likely to be racially (P
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Am J Clin Oncol Source Type: research

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Conclusion The temporal patterns of breast cancer incidence and mortality in Russia are in line with other countries in Europe, although cervical cancer rates and the risk of occurrence in recent generations is rapidly increasing; these trends underscore the need to place immediate priority in national cervical vaccination and screening programs.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
AbstractObjectiveTo examine the effect of the aqueous extract ofLigustrum robustum on tumor growthin vitro andin vivo and explore the possible molecular mechanisms.MethodsInin vitro study, cell viabilities of human cervical carcinoma cells (HeLa), human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), human hepatoma cells (7721) and human colon carcinoma cells (SW480) were evaluated with cell counting kit-8. ForL. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining. Mitochondrial membrane potential was measured by staining cells with JC-1. Apoptosis was monitored by ...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
Conclusion: It was found that the number of programmes implemented by particular local government units and the financial resources employed in the implementation of the programmes were different. It is probable that some of the initiatives of local government units related to secondary prevention coincide with the actions undertaken under the National Programme for Fighting Cancer. The entities that carry out breast cancer and cervical cancer prevention programmes need to coordinate their actions. PMID: 29774114 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractMethotrexate (MTX) is a folic acid derivative that is used for the treatment of different malignancies, whose applications have become limited by its toxic dose-related side effect and the possible initiation of drug resistance. The aim of the present research is to study the enhancement of the cellular cytotoxicity of MTX as an anticancer drug by conjugation to the synthesized polymer dots ’ (Pdots) surface. This conjugation was developed covalently by carbodiimide chemistry and characterized with Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), and UV–Vis spectroscopy. ...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29766645 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
Conclusions: Our study shows that the ASMRs of breast, cervical, and ovarian cancer remain high in Singapore compared to Japan and Korea. Generally speaking, the mortality risk of three cancers increased with age, and period and cohort effects may collectively affect the common female malignances mortality for East Asian women. PMID: 29750160 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: 1 August 2018 Source:Inorganica Chimica Acta, Volume 480 Author(s): V. Gomathi, R. Selvameena Expedient synthesis of Co(II) and Ni(II) complexes contriving the general molecular formula [M(L1)2Cl2] have been exemplified, where L1 = 4-((3-ethoxy-2-hydroxy benzylidene)amino)-N-(pyridin-2-yl)benzenesulfonamide. The structural feature of the complexes has been deduced from elemental analysis, molar conductance, magnetic moment, thermal analysis, IR, Far IR, UV powder XRD and EI mass spectra. The structure of the Sulpha pyridine Schiff base has been confirmed by single crystal XRD. The fluorescence quench...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
This article reviews some of the more common types of cancer that may be encountered during pregnancy. It reviews the unique challenges with the diagnosis and treatment of breast, cervical, hematologic, and colon cancers in pregnant patients. PMID: 29747725 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Obstet Gynecol Clin North Am Source Type: research
Abstract Cancer is the second leading cause of mortality worldwide. Therapeutic approach to cancer is a multi-faceted one, whereby many cellular/enzymatic pathways have been discovered as important drug targets for the treatment of cancer. A major disadvantage of most of the currently available anticancer drugs is their non-selective cytotoxicity towards cancerous as well as healthy cells. Another major hurdle in cancer therapy is the development of resistance to anticancer drugs. This necessitates the discovery of new molecules with potent and selective cytotoxic activity towards only cancerous cells, with minimu...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Abstract The encapsulation of Pt and Au-based anticancer agents within a protein cage is a promising way to enhance the selectivity of these potential drugs. Here a cytotoxic organometallic compound containing platinum(II) and gold(I) has been encapsulated within a ferritin nanocage (AFt). Inductively plasma coupled mass spectrometry data, collected to evaluate the amount of Pt and Au within the cage, indicate disruption of the starting heterobimetallic complex upon encapsulation within the nanocage. The drug-loaded protein (Pt(II)/Au(I)-AFt) has been characterized by UV-Vis spectroscopy, circular dichroism and X-...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
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